ID   A0A158Q668_DRAME        Unreviewed;       654 AA.
AC   A0A158Q668;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Rho GTPase-activating protein 26 {ECO:0000313|WBParaSite:DME_0000922601-mRNA-1};
GN   ORFNames=DME_LOCUS2963 {ECO:0000313|EMBL:VDN52990.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000922601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000922601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN52990.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYYG01000092; VDN52990.1; -; Genomic_DNA.
DR   STRING; 318479.A0A158Q668; -.
DR   WBParaSite; DME_0000922601-mRNA-1; DME_0000922601-mRNA-1; DME_0000922601.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01249; BAR-PH_GRAF_family; 1.
DR   CDD; cd11882; SH3_GRAF-like; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR047234; GRAF_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR047225; PH_GRAF.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR   PANTHER; PTHR12552:SF1; RHO GTPASE-ACTIVATING PROTEIN GRAF; 1.
DR   Pfam; PF16746; BAR_3; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          244..361
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          368..553
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          595..654
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
SQ   SEQUENCE   654 AA;  75409 MW;  9F6AE1B8383E0563 CRC64;
     MVLQPLEFAD CLADSPWFRQ NLHEHEVILE ETHKNIKTIE LLCRDLVQCT RKLSAVQRAF
     AKSLKEFKFT VVGNNQTDDE RKISECLSKF ADFVNQIEDH REKIVEDSET HYIEPLKKFR
     IDVVGRVLHE DKKRYEKESN KFYASLEKHL HLSTARKNDF KEADAQLDIQ QRNFWKSSLD
     YVTAIQSAQE RLKFEFVETL SSFLYSWLTF YHVGMFNIYF GFIVFLVFQT QNLSSENQPG
     SNLTSIKQGY VFVQEKSKIP KTIGRDVLSS RWTMYYCVYQ KETRIFTMIP SNSSTKTDMR
     GALGQSVSFK VKSCTRRASD TIDKRFCFDI LAVNRTESLT LQALSEEDRR QWLDAMDGRE
     PYSFKILAVL DDMGFDFIGK CLEIIEQKGI SEQGLYRNCG VSSKVQKLLQ SGLDKRKIIR
     KASTIDDVEW EIKTVSSAVK TYLRNLPEPL MTFDLHNNFL NAAKMDSVKR ISHIHYYVYQ
     LPKMHFAMLK MIIMHLKKVA DHSDENLMTI GNLGVCFGPT LLRPKEETMA AIMDIKFCNV
     VVEVLITNCD LKCLEDYANY YKAGVTVNGL GVNEGSGHLL DFRIENNNRI IGNIKRARRV
     KTLYVCIAGH DTELSFQPGQ IITNVYESKE EGWLVGTLNG KTGLIPANYV EPLP
//