ID A0A158Q7M6_9BILA Unreviewed; 4628 AA.
AC A0A158Q7M6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Dynein heavy chain, cytoplasmic {ECO:0000313|WBParaSite:EEL_0000499301-mRNA-1};
OS Elaeophora elaphi.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000499301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EEL_0000499301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 1147741.A0A158Q7M6; -.
DR WBParaSite; EEL_0000499301-mRNA-1; EEL_0000499301-mRNA-1; EEL_0000499301.
DR Proteomes; UP000050640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1882..2017
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2185..2337
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2578..2728
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2921..3082
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 539..566
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3218..3273
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3402..3464
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4628 AA; 528929 MW; 33D1E974F9B15737 CRC64;
MISIAPPDSS LSLVHAEPCE EALIKHRRIV TLVDIRTLVD YVKHEFIDAA AAALEEAFSQ
SGNVECVQKF ISDPQVPMLV VDRIVTRDLD TNPDDAVEDV TSVFRISNET AKRTERTTSL
LLLKSGTSVE GDKPVEDQLY VVRIPEGNTY DVLLSIFGRI GTPLFKSLVD YGRGERDGDK
LALSVEKHLS EVEVALLHMQ QNIDIPEINL TIHPVIQNTI QQAAEKGQKA RVTDLGNLVE
SSVFLNALHK GVNRWVKEIQ KVTKLDRDAG SGTSLQEMTF WLNLERALQK IAQKRESDEV
TLTLEALKCG KRFHATVSFD ADTGLKQTLA MVNDYNVLMK DLPLNELMAA TDMNGIKNAL
ANIFTHMRKL RNTKYPIARA LRFVEAISKD VSTQMLKALG TRRLMNIPLG DFDNLMAQCF
AVFSTWNDEY DKLATLMRDL SKKKRDEQLK LTWRLNPQHK KLESRLDQMR QFRRQHEQLR
TVISRVLRPV GQKEEKRSDS DVEKTSTLNA PELSAIEQVN TAYENVKEVD CLDVSNDGTI
AWEAAIRRYE DQIDRVETQI TAKLRDQLGG ARNADEMFMI FQRFNALFVR PHIRGAIREY
QTQLIQRVKE DIDKLQTRFK NFNEADNARI LRSIDIPPVA ASILWIRQID SKLTQYMKRI
EDVLGRGWEN HVEGRQLKLE GDNFRQKLNT QHIFDDWVAR VQAKNISLTG RIFIIEKRQK
DGKIALNLKV NFSSDVVTLF KEVRNMKHMG FRIPLKIVNT AHQANLLYPF AISLLESIRT
YDSINERIAN KPGVNMLIVA YKKDIQGQLA EGNSLTWESY KMDPYVVKLS SSINNFQEKV
EELDILLDRI EVDLAALDTC HYTSATIGSL LDSIQKAVDQ LSLGNFSNLH HWVNSTDAKM
RTLQIQIAKK LASRVEEAIH LWTIVLANDE FEDESDEKGT LPVLQPIVLE MRVTSQVMYV
SPSIEQARAH LLDQLFAWQS IITNQPRISS TRFQLTLTKD STEATYRDVL AHLPQGQKII
EQAYNTVEKV MKEVTDYVGE WLRYQALWDL QPDVLYERLG SDVSKWMKTL IEIRKSRATF
DTQETRKEIF PVVIDYTKVQ SKVSLKYDYW HREILQKFGS SVGQEMQTFF SDISKWRNEL
EEQSVDSGTT TDAIQLITYV QQLKKKTKIC QDKVEQFRAA QRLLTQQRYQ FPNSWLYSEN
VDGEWSALSE ILERKDSAIQ AQVANLQTKI KEEDEMVEKR TQDVLADWDK YKPVQGTQRP
SEALVALATF EAKLSKVKED RANMVKAKGA LEMAEPVFTA SHAAKLDIAV EELSDLKGVW
QSLMPMYDAV DELKEKTWLS VQPRKLRQSL DELLAQLKQL PAKYRSYDSY EYAKRMLHNY
SKMNMIVVEL KSDALKERHW KQLMKELRVS WNLSDLTLGQ VWDADLLRYE SAIKQVLLVA
QGELALEEFL KQVREYWQSF EVDLVNYQNK TKLIRGWDDL FSKLKEHMNS LTAMKLSPYY
KQFEEDALAW EEKLNKISAL FDIWIDVQRR WVYLDGLFSV SADINTLLPV ESSRFSSIST
EFLALMKKVT STSRILDIVN MQGSQRLLER LADMLAKIQK ALGEYLERER NSFPRFYFVG
DEDLLEIMGN SKDITRVQKH LKKMFAGISA IDVEEDNTLI TAMSSREGER VQLMRPVNVK
ENPHINDWLR MVECEMRNTL AHLLNQSLSI FSKFDMNSVE PQEYMAWLDQ FPAQIIELTA
NIWWCSNIEK HFAEGKTVET IEDVVEKTLS LLADSVLSEQ PAIRRKKIEA LVITEFVHKR
DICRCLIQNK VVSATSFYWS RCMRFYFDPR QLDPHSCCVM KMANAHFPYG FEYLGLQEKL
VQTPLTDRCY LTMTQALNSR LGGSPFGPAG TGKTESVKAL GHKIGRFVLV FNCDETFDFQ
AMGRILVGLC QVGAWGCFDE FNRLEERMLS AVSQQIQTIQ EAVRAGGQMQ VDLVGKTLSV
NSNMAIFITM NPGYSGRSHL PDNLKQLFRS LAMTQPDRQL IAQVMLFSQG FRTAEKLAKK
IVPLFILCKE QLSDQCHYDF GLRALKYVLV SAGNIKRDEI QRMIGNRSNI SEADISSETS
EQQILIQSVC ETLVPKLVSE DIALLFSLLS DVFPAIQYKP SRMDELRSEI AKVCDQLLLC
QSSTPGELGS AWLEKVLQLY QITNLNHGLM LVGASGSGKT TAWRVLLKAL ERLEGVEGVA
YVIDAKAMSK DALYGVLDPN TREWTDGLFT HIIRRIIDNV RGETSKRQWI VFDGDVDPEW
VENLNSVLDD NKLLTLPNGE RLGIPSNVRI IFEVADLKYA TLATVSRCGM VWFSDETITC
EMLFDNFLKR LRNVRLDIEQ SVDLLSLNVG SEEGGITPEA ERVINLQRKC AHCLTQHMSA
DALVPLTMKY ALTELDHIMV PTQQRMISSF FSMMNYTVRQ LINYDNAHAD FPMPAIFNYF
FNLIFLTWSY CELDDQIEAY ISHSMLVNIV WAFSGDSKWK SRQQLSDFMR QSSTLSLPPN
TALPVIDYEA AFSGEWVQWV SKVPQMEVET HRVAAADLVI PTVDTVRHEM LLNTWLSEHK
PLVLCGPPGS GKTMTLLSAL RSLQDMDVVN VNFSSSTTPE LLMRTFDHYC EYRRTPNGVV
LSPVQISRWL VIFCDEINLP SPDKYGTQRV ISFLRQLVEM NGFYRVSDQT WVSLERIQFV
GACNPPTDPG RHPLSLRFLR HVPVVYVDYP GQTSLLQIYG TFNRAMLRMA PSVRSFADPL
TNAMVDFYLQ SQEHFTQDDQ PHYIYSPREL TRWVRAISEA ISPLDSISPE ALVRLWAHEA
LRLFQDRLVR DDEREWTDHL LDTTAEKYFG ASCDLKQALE RPMLYSCWLT KHYLPVSKEQ
LKEYVTARLR SFYEEELDVQ LVLFDQMLDH VLRIDRIYRQ PQGHLLLIGT SGSGKTTLSR
FVAWLNGLSV FQLKVHSKYT ASDFDEDIRT VLRRTGCRNE KVCFIMDESN MLDTGFLERL
NTLLANGEVP GLFEGDDYTT LMSQIKEDAH RQGLMLDSPD ELYKWFTAQV MRNLHVVFTM
NPSGEGLRER SSTSPALFNR CVLNWFGDWT DSALYQVGME LTNTLDMARP EYQAPLTLPA
VCDLLPSPVQ YRHAVINTFV HVHNSVRKVN ENEAKRGHRV MALTPRHFLD FIKHYINVFH
EKRRDLEEEK LHLNIGLNKI RETEEQVLEL QKSLTLKSSE LETKKAAANA KLKEMLADQQ
RAEKEKLASE QLQKELAESL VEIEKKRAEV QKDLAQVEPA VEEAKQAVKG IKKGQLIEVR
SMAAPPQPVR LTLESICLLL GENVGTDWKA IRGVMVKDDF MPRILNFDTD SISAETLKIM
EKYTRNPDWD FDKSPTCSRI QVNRASSACG PMIKWMKAQL LYSDMLRKVE PLRNELERLE
KDAKVKTAKG EDLKKTIAKL EQSIAAYKEE YAQLIGQAEA IKADLATVKE KVGRSTQLLG
SLGSERDRWN GSCDGFSQQM DSLIGDALLS AAFLAYSGYY DQQLRDLLLH RWTSFVEQAD
IKHRSDLARV EYLSSVDERL EWNKNGLPVD DLCAENAIML HRFNRYPLII DPSGQAINYL
MKQFAGKNIT KTSFLDDSFR KNLESALRFG NSLLVQDVES YDPILNPVLN REVKRTGGRI
LIRLGDQDID LSPSFQIFLI TRDASVEFAP DLCSRVTFVN FTVTRASLEM QCLNQVLRSE
RPDVDEKRND LLKLQGEFAV RLRQLEKALL AALNESKGKI LDDDSVISTL EKLKNEAAEV
GRKAAETDKV MAEVEAVSQH YSRLAQACSL IYLMLQQLNE VHFLYQYSLD FLLEIFVAVL
VSPQLKSVTD YEQRLKIIMS NLFQMVYRRV SSGMLHQDKV LLALLLMRIV LKGNTSERSY
QLELDHLLGR SEIFTSQKQA DGAESLQGVN AQQMASLFLL SRLPAFADVV KKVSSSVDFR
NWVMLDNPEL NVPILWDDDD KLTEIGRCIN ELLVIYALRP DRLLASSHRL IAAAFGDEYM
QEDKGVNLRE IVENEVNANR PILLSSAIGF DASGKVEDLA IEMGREVTPI AIGSAEGFSQ
ADTVLNSASK SGRWILLKNV HLAPSWLAQL EKRLHSLKPH PQFRLLLTAE IHPKLPPQVL
RASRVVVYEP ATGLKANLLR SLSSLGPQRI TKPPAERSRL YFLICWLHAI VQERMRYIPL
GWANSYEFSD ADLRVACDTL DTSVDAVAMG RANVSPEKLP WHTLRCLLSQ CIYGGKIDNK
FDQMLLDCFL EKLFTAKSFD ADRVLISNID GKGTDLCIPD GNSREHFIHW VEKMPYLQLP
YWLGLPNNAE KVLLTVRGET MLANLLKVSD EELAFTGDDQ KTQSPPWMSV LAEQSSQWLK
LLPKNIPKLK RSMENIKDPL FRFFEREVNH GTHLLASVRS DLIEVQSVCR GERKQSNHTR
ALTVALNKGL VPADWLRYTV PKVLTVMTWI HDFTERVQQL IRLAGSASLK KESIWLGGLF
APEAYITATR QTVAQSNQWS LEELRMHIEV GATDDRPDTF RVEGLQLMGA ACKKKNELEI
VDEVSTDLEN VTLSWSREMS PPNSITLPVY LYRDRKNLLF TLDFNPGEVQ KTSLYERSVA
LASNSSLS
//
