ID A0A158Q7Q4_9BILA Unreviewed; 3928 AA.
AC A0A158Q7Q4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
OS Elaeophora elaphi.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000526301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EEL_0000526301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 1147741.A0A158Q7Q4; -.
DR WBParaSite; EEL_0000526301-mRNA-1; EEL_0000526301-mRNA-1; EEL_0000526301.
DR Proteomes; UP000050640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 3..393
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 858..1255
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1373..1702
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1837..1926
FT /note="Cytoplasmic dynein 2 heavy chain 1 AAA+ ATPase"
FT /evidence="ECO:0000259|Pfam:PF21264"
FT DOMAIN 2321..2524
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2572..2733
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2887..3106
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3348..3458
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3489..3624
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3632..3925
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 240..267
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 415..475
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 823..850
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2767..2831
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3047..3074
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3928 AA; 449829 MW; 06905FC72A88B1B0 CRC64;
MSDIWKNDTT DTMIDTLHAV ISVCEQWKFA ITTLVEKWKR DIDNPWKGGK PMISIFEILH
KHTDKILSLK LLSNQMDELV GDKNGRKEME QIIRNIFGTM PIFTCDISMQ QNWENKSLEA
ERSIEPIVER ALPVLRKRLQ FNQLTDDAAI NNLIKFKHFL NRPSIKEKLS MERETLLNRL
ANAVETQKRE LIERITNSDV PVGQYLTEIA AKLIWIRREI NKVENIKIVC DELLNDLTTY
KTIEAKIQEA IDEMHSLESD SLNLKSNFFS RLIDKYFRCQ EMIQAVSNST SSIALETSGK
LMSIEQKGGN LIVNYSDRLV RLLREVRQLT GLGFVIPRKI IECANTGEQF YKYAIVLKQV
AHFYNSVDQQ MLPCQQAMML DEALSFEKLI LSGKKGETTT NMVSWNDPKH LQEFIAKLQA
AAERLTLRNR HLRKAHSEIC EKIKELLNLD LLKEINKWKD VMVEIRSKIA EQERNIGSRS
NIIPWLSHWD HQLYKTLQLQ YQWGIESLHM QIPLIQVQLI FKDQQLELRP PLEEIRAKYY
RELRKFISIP QKFRGVQETE QANELFAKMI DHNANRFWSV YEKAEQLFEN LVNVGSEFES
WVVIGQVDLE SLITKHFKKA ADWENQIKLL KGKGRDAEKL PSEVRLECIL VSTSAVKIAI
DDMLQRLFDT LIWTLRYSIN NEIHDINHFL NQAIELLSSR PQSVAEIAEA NQKHIEFGKC
NKEMKRTLDL IEEKNVLLRS VGGSGAEQLP TVLSLWEKFE LMLDSHQLMI KEQVEILKSN
VGARMKSLIG EIEKLFVRWN QFKPKNDLLD DDRNAMLRAI QFIKEKREEF DELQEKRNAL
LTECEQFDIE KSEIPLFDEM AIDLENCENN WLLYEQFNVG LQEMADEEWI LSKTYRFDEY
LHEWDDKLKN LPVTHITVRL RKEIDQFKEM SAGLKYCRGE ILSSDHWLML FRILGMPKGT
TLEHLRFGDF LNVHKMIIEN LEALKNLNDR AQGEVTIREA IQELELWAEQ AEFVLFDYKH
SNGTVVKIIR DWKDALNSVK DSEALLQSLK NSPYYAQFTD KTSIWETRLA DTEQYVQWMN
EIQRKWIYLE PIFGRGSLPS EASRFSRVDV EFRGVLNDVV GDPRIVSLSM RGSLKRTLEQ
IIDQLNRCQK ALNQFLEEKR NAFPRFYFLG DDDLLEMLGQ LMNAAVIQAH LKKLFQGIHK
VVLGDNGETI IAVVSSDGEI VQLSKQVRIV PEAERWLQEL SDEMKNTIRK LIVSCVAETS
PDPGKYPSQV LCLSEQIRFC ERCERILSGR GDLQSYRKQL KQTLANYINS KTTDQVLKLK
LKALIMDVIH NISIVDELID NSPCHKSSWK QLRFYLESKE CVVIQHIGTR FDYTYEYQGN
VPKLVHTPLT DKCYLTLTQA MSMGLGGNPY GPAGTGKTES VKALASLFGR QVLVFNCDEG
IDIYSMNRIF IGLVQCGAWG CFDEFNRLDQ SVLSAVSMQI QVIQDAIKSR SGKCMLADRE
VPVDLNSAIF ITLNPASKGY GGRQKLPDNL KQLFRPIVMS VPDNEIIAET LLSSEGFCDA
KKLSRKLVSI FSLSKEMLSS QQHYDWGLRA LKTVLRSCGN LLANRVDKNE VQVVVDALTL
NTLSKLTFED SKRFSTLIDD IFSDVKKDTM QIAELLEPLK LVADEMKITV TDMQMKKIFE
LYDQMFQRMG VILLGPSGSG KSTIWKVLQK AMGRINKPVK IYRINPKSMA KQKLLGYMDM
DTREWSDGVL TAAAREVVKD SSVSAWIIFD GDIDPEWIEA LNSVLDDNRL LTMPSGERIQ
FGSNVNFIFE TDNLSNASPA TITRMGMILV SEEDMSIQEL INNWLKEYND VHPDMSIWIR
DHLYRCLDWI WTKGVIEISV SKTATVKNAL SHLRDVTSYN EFLVALYRGL APNISLKSRN
QFATEVVFNE VSLPDKLNPG NVYYDKRAGS LLTYTDEMCM ASNNDQLLNL ERYPYILTAN
AQANRDTICS WLDNRNRQPF IIYGADGCGK ESLLRYCLEL DPNSQIAILH CSAQTESQQV
LDLLHQYCVQ VSSASGKVLK PKEKQNLVLY LKAINVVKPD KWGTCEIIAF LQQLLTYKGY
YNEKLEWISL ENIQLVLSIT LANDEGHYLL PQRFVSLLRI CTVEYPTKEE LITIYSSYLA
ILIKDLSEPL RYRLNDLAST MVHLFNDVRN AFKPTDKAHY VFTLKDLSNW VFALTRYDIT
GTNIGEKFLY SMLYECRRIF KDRLVDDEHK QRFEDIISHN LSSAGVRNDE DNLFVSAQGA
VSITMLKGAP LSMVSRKDYA KLLQEAVNRY EFEIANFKMP IFDEFVKLCS QIDRVITAPG
GSLLLAGRAG MGRREAASLV ANMHQMPVFS PKLTSFYGIK QFRNDLKTII QDAAINGQHV
VYIVEDYQLL HEAFLQSINS LLSSGNLPGI FSGQEFDSFL VSLREQASQD AFQGDLYSYF
VMKVKANLHI ILILNVDDAN FSIKCSSNPS LYKECSIIWN ETWNKDALSQ LSELILSRHN
VKAPSDIVIA FGQIYHQCPP EIAPPAKYIR FIENYVCILN KKRTAIETRS NRLKAGIGKL
TEARESVSNM QKKAAKKSKL LAEKQTEADM TLKAISQSMT NTNYQRSDME QLKLATVKEN
ERIEKQKALI DEQLREVEPV LREAREAVGS IKSESLSEIR SLRAPPEAIR DILQAVLLFM
GIFDTSWEAM RKFLARNGVK DEIINFDARR ISPDVNKKNA KRASAAAAPL AAWVRANLDY
STILERVAPL QKEKNDLIKN LNEAEKQMEK LSKGLETVDE RETINVAGTL IDRLSGEYGR
WQKQIGNLQN DLDCLEKGSL LSAAFVTFLG SESERIRNEI LSKWQKLLNL NNFNLLEFNV
METEKLNWSN KGLPTDALSQ ENAMILFNTV EIPLIIDPSG RASSFLEKHL EDKQVEKVNA
NDSNFLTQVE LAVRFGKFLL IDDANRIEPT LMNLLRKEFS SQGPRHIVQI GEKAVDYNDN
FRLYICSKNN LLPLDQTSKA SVALICFSIT QTGLASQMLG LAIRIEKPAL ETRLNELTSN
VEQMKIKLDG IEQSLLQTLA SSEGSLLDNT DLLDSLNKSK ENAETIATSL VEADKLQKQF
VKEKDVYRPL AETASNLYFI IHDLRKQDPM YNFNLNTIIN LYSRTFRKVE EGTNAVGRME
KLRQILQHAV YEYVSRAIFK KDRLMFSMRF IHGIQPSLFA QNEWELFTGL IVDDATVYSM
ELIDWIGNER KASVAKLQKY LPTLFNNLRL TDQGLWSEFA RTINCETTFP PAIDTVITAF
QKLLVIQAIR PDRLYSAVIS FVTNVLGVSS INPSPLDLKS IYKSESNENE PIMILISPGA
DPSQELEELA RKQVSGAKSY QISMGQGQRQ AALEAIRMCA ANGGWVCLKN VHLAINDLAA
IEKEFMASKR DPSFRLWLTS ESNEHLSPQL LETSLKIVYE ASPGIKNNMK RIYAQWQQSE
LNFNAVCLQS LFMLAWLHAL LQERRMFIPE AWSKFYEFSN SDLRVAKKFV EDVTKNDKAV
DWQLLRGLMQ TVAYGGRIDN DFDMNVLMVY LRRYFNSSVI GMNGPGIAHN ISVPFSSNIR
DYINIINTNI PEEDNPALFG LPSNISITRD MAEANKTIRQ IRSMQIVVAN EITFDRNAWN
KALNPILTLW KRLNSQSTLH SMNVPSVQHT DDLILEIISL EYVYAVILVQ KVHKFLGAIS
KCLRGIQLFT SEIANSAREL MMHQTPEEWQ EAWRGPSDPD QYLSVLMHKA KSIEELSRIN
DSRKILANPV RLGSIFRPTA FFNALRQLTA RRKQMSMDEL KLGTAWNAAF LKNEDVMEIS
GIHIQGALFE EHIAETKQTS PPVTTAPNLY IAWISADAPD VYEKEKSIFV PLYATLERNQ
LIAEVQMPCT ENPARWIIAS VALFLSNQ
//