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Database: UniProt
Entry: A0A158Q7Q4_9BILA
LinkDB: A0A158Q7Q4_9BILA
Original site: A0A158Q7Q4_9BILA 
ID   A0A158Q7Q4_9BILA        Unreviewed;      3928 AA.
AC   A0A158Q7Q4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
OS   Elaeophora elaphi.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX   NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000526301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EEL_0000526301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   STRING; 1147741.A0A158Q7Q4; -.
DR   WBParaSite; EEL_0000526301-mRNA-1; EEL_0000526301-mRNA-1; EEL_0000526301.
DR   Proteomes; UP000050640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR049400; DYNC2H1_AAA_dom.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          3..393
FT                   /note="Dynein heavy chain tail"
FT                   /evidence="ECO:0000259|Pfam:PF08385"
FT   DOMAIN          858..1255
FT                   /note="Dynein heavy chain linker"
FT                   /evidence="ECO:0000259|Pfam:PF08393"
FT   DOMAIN          1373..1702
FT                   /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT                   motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12774"
FT   DOMAIN          1837..1926
FT                   /note="Cytoplasmic dynein 2 heavy chain 1 AAA+ ATPase"
FT                   /evidence="ECO:0000259|Pfam:PF21264"
FT   DOMAIN          2321..2524
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          2572..2733
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   DOMAIN          2887..3106
FT                   /note="Dynein heavy chain ATP-binding dynein motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12781"
FT   DOMAIN          3348..3458
FT                   /note="Dynein heavy chain region D6 P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF03028"
FT   DOMAIN          3489..3624
FT                   /note="Dynein heavy chain AAA lid"
FT                   /evidence="ECO:0000259|Pfam:PF18198"
FT   DOMAIN          3632..3925
FT                   /note="Dynein heavy chain C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18199"
FT   COILED          240..267
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          415..475
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          823..850
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2767..2831
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3047..3074
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   3928 AA;  449829 MW;  06905FC72A88B1B0 CRC64;
     MSDIWKNDTT DTMIDTLHAV ISVCEQWKFA ITTLVEKWKR DIDNPWKGGK PMISIFEILH
     KHTDKILSLK LLSNQMDELV GDKNGRKEME QIIRNIFGTM PIFTCDISMQ QNWENKSLEA
     ERSIEPIVER ALPVLRKRLQ FNQLTDDAAI NNLIKFKHFL NRPSIKEKLS MERETLLNRL
     ANAVETQKRE LIERITNSDV PVGQYLTEIA AKLIWIRREI NKVENIKIVC DELLNDLTTY
     KTIEAKIQEA IDEMHSLESD SLNLKSNFFS RLIDKYFRCQ EMIQAVSNST SSIALETSGK
     LMSIEQKGGN LIVNYSDRLV RLLREVRQLT GLGFVIPRKI IECANTGEQF YKYAIVLKQV
     AHFYNSVDQQ MLPCQQAMML DEALSFEKLI LSGKKGETTT NMVSWNDPKH LQEFIAKLQA
     AAERLTLRNR HLRKAHSEIC EKIKELLNLD LLKEINKWKD VMVEIRSKIA EQERNIGSRS
     NIIPWLSHWD HQLYKTLQLQ YQWGIESLHM QIPLIQVQLI FKDQQLELRP PLEEIRAKYY
     RELRKFISIP QKFRGVQETE QANELFAKMI DHNANRFWSV YEKAEQLFEN LVNVGSEFES
     WVVIGQVDLE SLITKHFKKA ADWENQIKLL KGKGRDAEKL PSEVRLECIL VSTSAVKIAI
     DDMLQRLFDT LIWTLRYSIN NEIHDINHFL NQAIELLSSR PQSVAEIAEA NQKHIEFGKC
     NKEMKRTLDL IEEKNVLLRS VGGSGAEQLP TVLSLWEKFE LMLDSHQLMI KEQVEILKSN
     VGARMKSLIG EIEKLFVRWN QFKPKNDLLD DDRNAMLRAI QFIKEKREEF DELQEKRNAL
     LTECEQFDIE KSEIPLFDEM AIDLENCENN WLLYEQFNVG LQEMADEEWI LSKTYRFDEY
     LHEWDDKLKN LPVTHITVRL RKEIDQFKEM SAGLKYCRGE ILSSDHWLML FRILGMPKGT
     TLEHLRFGDF LNVHKMIIEN LEALKNLNDR AQGEVTIREA IQELELWAEQ AEFVLFDYKH
     SNGTVVKIIR DWKDALNSVK DSEALLQSLK NSPYYAQFTD KTSIWETRLA DTEQYVQWMN
     EIQRKWIYLE PIFGRGSLPS EASRFSRVDV EFRGVLNDVV GDPRIVSLSM RGSLKRTLEQ
     IIDQLNRCQK ALNQFLEEKR NAFPRFYFLG DDDLLEMLGQ LMNAAVIQAH LKKLFQGIHK
     VVLGDNGETI IAVVSSDGEI VQLSKQVRIV PEAERWLQEL SDEMKNTIRK LIVSCVAETS
     PDPGKYPSQV LCLSEQIRFC ERCERILSGR GDLQSYRKQL KQTLANYINS KTTDQVLKLK
     LKALIMDVIH NISIVDELID NSPCHKSSWK QLRFYLESKE CVVIQHIGTR FDYTYEYQGN
     VPKLVHTPLT DKCYLTLTQA MSMGLGGNPY GPAGTGKTES VKALASLFGR QVLVFNCDEG
     IDIYSMNRIF IGLVQCGAWG CFDEFNRLDQ SVLSAVSMQI QVIQDAIKSR SGKCMLADRE
     VPVDLNSAIF ITLNPASKGY GGRQKLPDNL KQLFRPIVMS VPDNEIIAET LLSSEGFCDA
     KKLSRKLVSI FSLSKEMLSS QQHYDWGLRA LKTVLRSCGN LLANRVDKNE VQVVVDALTL
     NTLSKLTFED SKRFSTLIDD IFSDVKKDTM QIAELLEPLK LVADEMKITV TDMQMKKIFE
     LYDQMFQRMG VILLGPSGSG KSTIWKVLQK AMGRINKPVK IYRINPKSMA KQKLLGYMDM
     DTREWSDGVL TAAAREVVKD SSVSAWIIFD GDIDPEWIEA LNSVLDDNRL LTMPSGERIQ
     FGSNVNFIFE TDNLSNASPA TITRMGMILV SEEDMSIQEL INNWLKEYND VHPDMSIWIR
     DHLYRCLDWI WTKGVIEISV SKTATVKNAL SHLRDVTSYN EFLVALYRGL APNISLKSRN
     QFATEVVFNE VSLPDKLNPG NVYYDKRAGS LLTYTDEMCM ASNNDQLLNL ERYPYILTAN
     AQANRDTICS WLDNRNRQPF IIYGADGCGK ESLLRYCLEL DPNSQIAILH CSAQTESQQV
     LDLLHQYCVQ VSSASGKVLK PKEKQNLVLY LKAINVVKPD KWGTCEIIAF LQQLLTYKGY
     YNEKLEWISL ENIQLVLSIT LANDEGHYLL PQRFVSLLRI CTVEYPTKEE LITIYSSYLA
     ILIKDLSEPL RYRLNDLAST MVHLFNDVRN AFKPTDKAHY VFTLKDLSNW VFALTRYDIT
     GTNIGEKFLY SMLYECRRIF KDRLVDDEHK QRFEDIISHN LSSAGVRNDE DNLFVSAQGA
     VSITMLKGAP LSMVSRKDYA KLLQEAVNRY EFEIANFKMP IFDEFVKLCS QIDRVITAPG
     GSLLLAGRAG MGRREAASLV ANMHQMPVFS PKLTSFYGIK QFRNDLKTII QDAAINGQHV
     VYIVEDYQLL HEAFLQSINS LLSSGNLPGI FSGQEFDSFL VSLREQASQD AFQGDLYSYF
     VMKVKANLHI ILILNVDDAN FSIKCSSNPS LYKECSIIWN ETWNKDALSQ LSELILSRHN
     VKAPSDIVIA FGQIYHQCPP EIAPPAKYIR FIENYVCILN KKRTAIETRS NRLKAGIGKL
     TEARESVSNM QKKAAKKSKL LAEKQTEADM TLKAISQSMT NTNYQRSDME QLKLATVKEN
     ERIEKQKALI DEQLREVEPV LREAREAVGS IKSESLSEIR SLRAPPEAIR DILQAVLLFM
     GIFDTSWEAM RKFLARNGVK DEIINFDARR ISPDVNKKNA KRASAAAAPL AAWVRANLDY
     STILERVAPL QKEKNDLIKN LNEAEKQMEK LSKGLETVDE RETINVAGTL IDRLSGEYGR
     WQKQIGNLQN DLDCLEKGSL LSAAFVTFLG SESERIRNEI LSKWQKLLNL NNFNLLEFNV
     METEKLNWSN KGLPTDALSQ ENAMILFNTV EIPLIIDPSG RASSFLEKHL EDKQVEKVNA
     NDSNFLTQVE LAVRFGKFLL IDDANRIEPT LMNLLRKEFS SQGPRHIVQI GEKAVDYNDN
     FRLYICSKNN LLPLDQTSKA SVALICFSIT QTGLASQMLG LAIRIEKPAL ETRLNELTSN
     VEQMKIKLDG IEQSLLQTLA SSEGSLLDNT DLLDSLNKSK ENAETIATSL VEADKLQKQF
     VKEKDVYRPL AETASNLYFI IHDLRKQDPM YNFNLNTIIN LYSRTFRKVE EGTNAVGRME
     KLRQILQHAV YEYVSRAIFK KDRLMFSMRF IHGIQPSLFA QNEWELFTGL IVDDATVYSM
     ELIDWIGNER KASVAKLQKY LPTLFNNLRL TDQGLWSEFA RTINCETTFP PAIDTVITAF
     QKLLVIQAIR PDRLYSAVIS FVTNVLGVSS INPSPLDLKS IYKSESNENE PIMILISPGA
     DPSQELEELA RKQVSGAKSY QISMGQGQRQ AALEAIRMCA ANGGWVCLKN VHLAINDLAA
     IEKEFMASKR DPSFRLWLTS ESNEHLSPQL LETSLKIVYE ASPGIKNNMK RIYAQWQQSE
     LNFNAVCLQS LFMLAWLHAL LQERRMFIPE AWSKFYEFSN SDLRVAKKFV EDVTKNDKAV
     DWQLLRGLMQ TVAYGGRIDN DFDMNVLMVY LRRYFNSSVI GMNGPGIAHN ISVPFSSNIR
     DYINIINTNI PEEDNPALFG LPSNISITRD MAEANKTIRQ IRSMQIVVAN EITFDRNAWN
     KALNPILTLW KRLNSQSTLH SMNVPSVQHT DDLILEIISL EYVYAVILVQ KVHKFLGAIS
     KCLRGIQLFT SEIANSAREL MMHQTPEEWQ EAWRGPSDPD QYLSVLMHKA KSIEELSRIN
     DSRKILANPV RLGSIFRPTA FFNALRQLTA RRKQMSMDEL KLGTAWNAAF LKNEDVMEIS
     GIHIQGALFE EHIAETKQTS PPVTTAPNLY IAWISADAPD VYEKEKSIFV PLYATLERNQ
     LIAEVQMPCT ENPARWIIAS VALFLSNQ
//
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