ID A0A158QNC6_HAEPC Unreviewed; 4558 AA.
AC A0A158QNC6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=EGF-like domain-containing protein {ECO:0000313|WBParaSite:HPLM_0001015001-mRNA-1};
GN ORFNames=HPLM_LOCUS10142 {ECO:0000313|EMBL:VDO39325.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001015001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0001015001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO39325.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO39325.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; UZAF01017225; VDO39325.1; -; Genomic_DNA.
DR STRING; 6290.A0A158QNC6; -.
DR WBParaSite; HPLM_0001015001-mRNA-1; HPLM_0001015001-mRNA-1; HPLM_0001015001.
DR OMA; RTCQPEQ; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 25.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 30.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 27.
DR Pfam; PF00058; Ldl_recept_b; 6.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 22.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00192; LDLa; 32.
DR SMART; SM00135; LY; 31.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 29.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01209; LDLRA_1; 12.
DR PROSITE; PS50068; LDLRA_2; 30.
DR PROSITE; PS51120; LDLRB; 10.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4393..4418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 312..354
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 396..440
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1355..1397
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1398..1441
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1442..1485
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1486..1530
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2044..2088
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2415..2465
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4165..4208
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4210..4251
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4346..4376
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4448..4539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4460..4480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4489..4514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 52..64
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 59..77
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 71..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 111..126
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 895..913
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 978..990
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 985..1003
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1019..1031
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1026..1044
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1080..1095
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1144..1156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1151..1169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2634..2652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2668..2680
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2675..2693
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2687..2702
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2708..2720
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2715..2733
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2795..2807
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2802..2820
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2848..2866
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2934..2946
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2941..2959
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2974..2986
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2981..2999
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2993..3008
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3493..3505
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3500..3518
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3512..3527
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3575..3587
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3582..3600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3700..3712
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3707..3725
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3719..3734
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3739..3751
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3746..3764
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3758..3773
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3781..3793
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3788..3806
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3871..3883
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3878..3896
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3890..3905
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4366..4375
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4558 AA; 504495 MW; 6A6E315F77F4BE94 CRC64;
QDSCSHNHTA CFQYQFRCAD QSQCVQKSWV CDGSKDCADG SDEPETCEFK KCSASEFQCK
NKRCQPRKFK CDYYDDCGDN SDEEDCGEYR CPPGKWHCNG TGHCIDELRL CDGVKDCDDG
ADELNCSQNL CPSLGCQAGC HASPHGGVCT CPNGYKLDER FHRTCSDVNE CAEFGYCDQL
CANHRPGFTC SCIGECYSLQ MVHGPGQDNL TARGYCISQN PETMKLFVAR REGLYRLDPT
GPNTEPKRLA SGEFIYGIDF DYGDRKIFWT DRLSHSAFSA DVDEAGDISH IKKLGLKSLV
YPRSLAVDWI TNTLYIIESG SRRIDVSSFD GDRRTVLLAD GLTLPLDIAL DPLRGEMFFT
NQFKVEGAAM DGSRRRTLIN THTHQVSGIV VDIPARRVYW VDPKVDRVES IDYQGNDRRI
VAQGMNNVPH PFGLALFDQY LYWTDWTRLG VVKIEKFGSP TEIIWSNKEN NVFPMGISAY
HPMAQPGPGQ SECLAQKIDN PCATADCEGM CILSKDSGGF GVGYTCACPI GQKLVEGKKC
IDSIDYLLFS SNKIVRGIFP DQVSNSLSEA ILPISPISQR RIGMYFEVEC DVHGNSFFYA
DIMDNTVYRI RPDGEGSAPV LVTHNDGLVS MSFDWISKQL YYIDNIRNSL EVVKISDTGL
VHPDQLMHRL LLRNLRDPVA VVIHPWKGLL FYAEAQRPAR IYRCHMDGTN CLVIRNTTLG
RPSEMAIDFE EDRLCWGDTL LKTISCMDFD GSKVVVLPID NPIPVALAIM GDHLYYVHQR
PYSIRRVSKK NGGTGRVIRE FSGEERSIFS LKACTHSNQP IPEDSQDHPC HSSQCAQLCF
AVPNNSSAND APKLVAQCAC RQGFKINPET GNTCQKDNSE QTEPLCTSNA TQYQCNNGRC
IPREWKCDGE DDCLDGSDEV DASGNKCYHE MECPENTIRC KNTKKCIPSQ YGCDGDNDCG
DYSDEDAQYC KDGQKPVCSA KKFQCDNHRC IPEQWKCDSD NDCGDGSDEK LEFCANATCA
VNQFSCANGR CIPIYWLCDG DNDCYDGTDE DKERCPPTQC RSDQFRCANG RQCISLRNHC
DGQNDCEDGS DEDSCLTQQN ACTSEQFECK SSGLCIPATW KCDGQKDCDD GSDEPAFGCA
ANTCKEDHFK CANGRCILNS WLCDGENDCG DGSDESAING CKKSQLSRRC PFEQVNCEGA
PDVCIPLTEL CDGKEQCPGG TDEGGRCARD LCSADRAGCA FKCHNSPNGP LCSCPFGEQL
VNKTRCEPEN ECLDASSCSQ KCTDEKHGFT CSCEEGYELD ADKRTCKVTD GAKDMRVYIS
NRNRIYWSDS HLENWRTFAA GVENAIAIAW DSVSDRIFWS DIREKKIFSA TRNGTNVTTF
IGDGLDITEG IALDWIGRNL YWVDSSLNTI EAANLDNPSA RVLLVHENIS QPRGIAVDPR
KGLMFWTDWG QNPHIARANM DGTDRKIIVS TKIYWPNTIA LDLTTDRVYF ADSKLDYIDF
VNYDGTGRTQ VLSSSKFVQH PHALAIFEDF MYYSDRRLQR LQVYPKYPNG TTGDYPNHTF
SKALGVTAVH PVLQPKAVKN PCEGNPCSHI CLLSSTGFSC GCPMGKRLDA AGRNCVVDQK
PFLLLIQKNN VFGVEMTSKP NTIPSLAGMI PLAGLANAFD AGYDADSGDI FVLEHTNIAR
TLTQISTDAA IYKSSINAGN KTQLYSSQIP DDPYCMAFDW NGRNLYVGNK ISQTIEVVRT
VGNQFRAVIL SNDQTPTAVV TPVSIAVDSD RGLLFWLDRG GGAADVKVAR ANLDGTGALV
IASNDLTELD HIALDTANQR VYFSEAKAGR ISSVTYDGQD RHYILNDAGK QPNGIAFFSD
RLFYADSAFD SIDVATIVGD GQPPQFTHFK KDIENLVNIK VLQPRASSIS HPCRTDNGNC
KHICVPQQFS QHTCICATGY TKDGPTSCKL FDESFVMVAT KTKVVGYPLD DSRQKGIAMD
PIGGLSITSI DFDFESKTIF VAEATGINKG ITAYAIGESA PRPIVRDTFG SMTIRSIAVD
WINFNLYFIN QDSERTNIEV CKLDGQYRKI LFTTKTETPS SIAVDPIGRY LYWADQGQKP
SIQFSACFLG WNSRYRLRCW NXEVVVGAEH VAEPTDVIVD PASRMIYWAD AKKDGIYRLS
LCIIPMSYST PISPPQLESR WQLELFTKTG NPLNKPNQTS LLLSPTTVAA SLKDLGDVVV
FSSENQPRGS SPCQITDNLR KSPCPQLCFS SPGTQSPSCA CARGVLKGRT CEEPDTYLMF
TDGDKIIDAS IEPDIKASRP LKEPFPAIDN LQVFDVDVNL RRIYYVTESP SGVNISWFSM
NNADNPRLVL GATKQKHAMD IRHVSDMKLD WLTQKIYFTT GRAGKVMSID SQGEHLSTVA
SGDWTYALAL DPCSGLIFWS DSGYKASGGL YEPRIERSNM AGGNRKVIVS ESVSLPAAIA
VDFRNLRIYW ADVNRLNIES SDYDGNNRKV IGAGYRAKSL DIWDQWLYMS DPLSNGVFRL
NKDSGGVIEP VVTDRRVPGT LRVFASENDV RTRNQICNAI TASLCKTDNG GCDQICTVIA
DEIGLAASKV QCSCNDTYEL VQEPGKDTPT QCVLRTGMDS GMAKECLPPY NFQCGDGACI
ALGVTCNGKP DCSDSSDENP NYCNTRSCPE NYFLCTNRRC IDEVKRCNHI DDCGDASDEL
DCAAAVTCAA GTFACGNGHC INQTKVCDGH NDCHDTGVSD ESKEACPGLP IDCRGVKIRC
PNTNICIQPA DLCDGYDDCG DKADENKLFC MNQQCAQHYV RCPSGRCIPE TWQCDGDNDC
SDGWDETHTN CTDENGKRIC VGEYLFQCDN GKCISRAFIC DGEDDCGDSS DEHTRHSCGN
RTCTDQEFHC VSNARLAQPK YECIPKAWLC DGDVTCAGGE DESAELCKTE KKECNKGEFR
CQNQHCIHQS WECDGDNDCL DGSDEHANCT YSSCQAEFWQ CANHKCIPNS WRCDGNDDCD
DGSDEKECAQ SQKVGYCLRS NLQSFQVCDR NYDCTDRSDE SSQCFIDECA QADKPLCEQK
CVDLPIGYRC DCFEGFAIDV DDKKSCHNVN ECYEGISGCS QTCEDKIGSY KCGCVEGYQL
GKDDHSCKRT QAEPVPWLML ANKHYIRKIS LDGNTYEMAA QGFDNVVSLD VDLTEKKVYL
VDQGKLRLLR VDIEEMDDPV SSYETVLRHN IFGIEGFAVD WVGRKIYMLN RQEKSIRVCE
LDGRFCRTLI RDRISQPKAI AIHPGKGYLF FTEWSLQPYI GRMALDGSPE LADPIVKLAE
NDLGWPNALT IDYYSNRLFW GDAHLNEIGF MDLDGGGRRH IPAQRTSHVS SMVVFDDYLY
WSDWNLREVI RCDKWTGKNE TVLKKTIQLP NDLRVIHPLR QPAYPNPCGT NNGGCSHLCL
IGAGGNGYTC ACPDQFVLLG DNKTCEPNCT DRQFACGGDD AKCIPKLWYC DGEPDCRDGS
DEPGKDICGI RICPVGEFQC SNHNCTRPFQ LCDGNDDCGD GSDEQECDKP CDPWMFKCVA
TGKCIPRRFT CDGDDDCGDR SDEADSLCLS PDRNCTAEEF RCTNNKCIAK AWRCDNDDDC
GDGSDETPDC AQVECRRGWT RCASSYRCIP NWAFCNGQDD CRDNSDENKE RCPTCDDIGE
FRCATTGKCI PRRWMCDSEN DCGDNSDETD PSCGGTSRPC SESEFRCNDG KCIPGSKVCD
GTVQCSDGLD ESQCTLRKCA AGHRQCDDGT CIVEHKWCDR RKDCPNAADE TNCSHVERRP
CSPFEFECSN SVCIPRKFMC DGDNDCGDNS DETSSECRSA QCDPPLRFRC AHSRLCLNIL
QLCNGFNDCG PNDYSDEHLS MCSSFSEYGD CNLDQFKCAN GRCINGSLPC DRNDDCGDAS
DEIGCTKRNG KTCESHNDNG GCKHLCTDVR DGYYCHCRDG FKPDPSNPFD CVDIDECAGN
NTCTQMCLNT KGSYLCRCHE DYENNVVVGA MTGKDCRAKG DPANIIVAAD DELVQVALHG
ARVNRHAAAQ AEQEDSDIVA IAFDPRRALQ FWLDGGTNFI YRASEPSGNQ SHAGQKLDLD
FGSLGVTPTS LAVDYLTGNI FITTVSNEEG IIAVPGARKK RMSEPSHNTD TGSIFVALSD
GRYLKKIIGG HLQMPTAIVT LPSVGRICYA DAGLHAKIEC ADMDGTHREI IVKDLVFSPS
SMAVDEGKGN RIYWADPKYK KVDSVNPDGT DRTTIVRDTN VPWAIDVFEN HLYWVCRETK
TLYVQDKFGR GRVSVLASDL EDVHAVRVSQ RYARDATRAK SACDEARCSH ICVQLPNDGF
ACLCPENVFP GTDGSCPVAR VDALVMPRQC KCTNGGRCKL DGSCECSSDF EGEFCQKSNT
VSRKLIGRIS ENLLLALFLL LALFACIGLI GFVGVNLYRK RTLLSKKNEA ADSSVSFHGN
VISFSNPALD SKQDPHPIEY SMHQITTSEP GSTTFSNPVY DLEADGTEMS TLPENTPSTS
RAESFRSQNR TGDDVIATGA ELTTKPVVPP RPTKVEKDKN ILLENPVFEA HPDEISDV
//
