ID A0A158QNL1_HAEPC Unreviewed; 1047 AA.
AC A0A158QNL1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=RING-type domain-containing protein {ECO:0000313|WBParaSite:HPLM_0001065501-mRNA-1};
GN ORFNames=HPLM_LOCUS10647 {ECO:0000313|EMBL:VDO40747.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001065501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0001065501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO40747.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO40747.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UZAF01017348; VDO40747.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158QNL1; -.
DR STRING; 6290.A0A158QNL1; -.
DR WBParaSite; HPLM_0001065501-mRNA-1; HPLM_0001065501-mRNA-1; HPLM_0001065501.
DR OMA; EEYIHRY; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd14954; NHL_TRIM71_like; 1.
DR CDD; cd16524; RING-HC_NHL-1-like; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24104; E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED; 1.
DR PANTHER; PTHR24104:SF54; THIN, ISOFORM C; 1.
DR Pfam; PF01436; NHL; 3.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51125; NHL; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 56..97
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REPEAT 707..748
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 752..794
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 798..841
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 961..1004
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REGION 368..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..524
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1047 AA; 117054 MW; A33215F6A1EB0B2A CRC64;
MLTEDRAASG IPVGMDASEE TAEARAKVRH LMAQAPNARP PEFVNPLEKI EQLLTCPICL
DRYKQPKLLP CQHTFCYPCL ESCADTLHRT LKCPECRAEH SIPYEGVKAF QSNYTLTGFL
EIHLQATPDS AAEIEEYIRR YNLERCKVCD EKADCELCAH CERKACKECR QTHMDMLKRD
LARLLNQVRR LSNRIIEASD GLSKGLELLT LNCETTKDEV KEYFHRHQRD LKKREDAFLS
EIDTFHATES RLMSNLRDVL EIESSNMSEA VARLDAVIKG ECTLDDAELV RLKTTFSEGL
EYLRNFQPDA DELFNRKLRF SAGEDAARLP QAITTCGELC VLVPQFAGRY LPLEQSYLPR
PFRLTLESDQ HRSRHGHEDS RANDRDRPSS RLTVRDLDES SIRYRRRQQL EEEAWNRLRG
TSAAMERNGT SSVTSTEREG STVGRSPWSR PPEASSLNAT PVPETTTPAS APKKEAPPVR
QAERAQASKP TPLNLPRPER AAQPRVDVSP APRSPKPPSS PAPLIRAAEP AKEETEEVRS
RKPPLPRQAS SNDESLNEKV EVIRRAHAER QAASRAASSE DSEAEEASRP RQRIRIVCRA
ASTTRDDEPI ATAASVPPGV PIPVTHFTGE PEIPAWLARR RQRFQRSRTN PDLASQFCSQ
RVQQLLQERD SRLDSSTSTE EERRNIRRRS ASREISEWRA RGCPRVIFGR KGAKEGELNW
PRGVCALRGG TLAVCDSSNH RVCVFDREGK FLRQFGGYGS GRGQLDSAAG IATFKSKLIV
SDRYNHRVCI FDSDGTYLNS FGGHGQSNGK FNNPWGVAVD ELGTIYVADK DNHRVQMFDK
NGLFVGKFGT NGHGPGQLHN PLFIAVNNAN HQVSPAANLR FEESSKCMVT CDNLSFLSLI
DLTTAAFTNI PIFQTLLSCL LVLAWCLLAT RGWGLSDFIQ VYVSDSSNHR ICVFDVQGMF
LFSFGTEGFH GGQFKFPRGV AVDSQSNILV ADSGNNRIQV FSSDGEFICT FGTWGGGAGQ
LKGVEALCVF DGGIVASDRE NHRIQIF
//
