ID A0A158QWF4_NIPBR Unreviewed; 1609 AA.
AC A0A158QWF4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=NBR_LOCUS67 {ECO:0000313|EMBL:VDL61934.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Trichostrongyloidea; Heligmonellidae; Nippostrongylinae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000006601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000006601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL61934.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
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DR EMBL; UYSL01000011; VDL61934.1; -; Genomic_DNA.
DR STRING; 27835.A0A158QWF4; -.
DR WBParaSite; NBR_0000006601-mRNA-1; NBR_0000006601-mRNA-1; NBR_0000006601.
DR OMA; PGIMAHF; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 350..681
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 1311..1416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1382..1409
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1609 AA; 181667 MW; 95185CDFB5301CF7 CRC64;
MDGLTTIRSG DEPYMQFDKL KLRNYFPHEI EKLSVLRIVQ TRSFDEIGHA IRGGLYDPLL
GPVEPRDRCE TCNQYEVYCP GHFGHIRLDV PVFNPMLYSF CFNLLKGSCV QCHRFTCGTD
GLATKVLLAQ LRCFELGVPH LAPEIETQFK EKLGSSLQSV FLNEEEELQM FAELDKLISD
RAGRPLSSLT AETPTKNTVD LRKNIIKNYL KNHLFKRKAR CPLCKAFNGQ LRNDGARCVL
IDFTVHGKKR KKLDIYKSGF EGEEEEEEVR SSDDEKEKKS ALINDTGYGT VEVSESALEI
QMRAVQSGAC EKLAWRAAEI REHFRLLYKT EGKLLLKLFP MLAGDLCPLD GLFCELIMVP
PTKFRPIRLF KGERYENPQT VNLRKVLEAT ETIKAVSLVL NGDKSPQLLE LIANRTQGKT
MNAKMHNAYL ALQQRVNAIY DEELDKHDQN RIPGIKQILE KKQGLFRMNM MGKRVNFACR
SVITPDPYLD IDEIGIPEIF AKKLTFTEPV NLFNKGHMRK VVRNGPNVHP GANFVMGNKK
QMLQPDDAAE DARAKRIALS KHLEPANTDN LRPPVKVLRH LRNGDMMMMN RQPSLHKPSI
QGHRARVITG QRALRMNYAP CKAYNADFDG DEMNGHLVQS HIAQCEVAEL ANVGSNFLVP
KDATPLLGLI QDHVVSGVLL TIRGRFLTKE DFMHLVLSAF AYRTKRIDIP PPAMIKPCQM
WSGKQVISCI IKNCVPKGKP LINLTSKAKT PLSCWKVRGF NAPQQNMSES EVVFRQGELL
VGVLDKQHYG ATQYGLVHSC FELYGHKVGV QILSCFSRLF TTYLQLHGFT LGVADILVRK
DADKLRKQAI RESRTIGDQV VRNAFGLDDN VSHAEINRIL ASTYCNPRGQ GQDVKMLDYS
MKQSIAKYND AITKACVPDG LIRQFPENAL QVMILSGAKG SAVNAIQISC CLGQIELEGK
RMAVTVAGRT LPSFRAYDPS PRAGGYIDQR FLTGINPQEL FFHTMAGREG LIDTAVKTSR
SGYLQRCLIK HLEGIRVHYD GTVRDHDGSV VQFRYGEDGL DVLKSTYISP KTFPFLKDNL
DAVTHCSKPE EARDSEYGVD GAEKQYRKIV KWRKKAGADG RPAKKEYRSG FTEFSIDQTG
VDKKRMVGMW AEMDEAERMV YEKRAPRKCP HAVDEEFNVN STLGALPEKT LDAIHKFSGE
NDRLRRSLFW KGMRSLVEPG ENVGLLAAQS IGEPSTQMTL NTFHFAGRGE MNVTLGIPRL
REILMTASDH IATPSAKIER RFLRALANAI TKKYSDVLEY QQVQHRKLRA GNLSAGLGQR
NAGAPTRRAQ NMDDGNSSDE EAAGGREADA AEQRLHNRHR DDAAEYEGEE EDRVHVEKDD
DDEQNEIGEA NEEGSEKEND DEDEEEEDEK DVTVPKKSAD ERIKYVISQS TLIVDYKYDV
KSERWCEVVF QLPLGNKSKE VERFIVHQTP GIERCIETEE TVRDVPTKFL QTQGINLEEA
LHGDTDFEEV EEFKASVDEV EDVVWTPEDD SVCDHIDDPS EKAIVRDGRT ITSSMAFFKH
ADVLDVNAIY SNDLNLILHQ YGVEACSRAI VQVSWAVTYF DASHKECFF
//