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Database: UniProt
Entry: A0A158QWF4_NIPBR
LinkDB: A0A158QWF4_NIPBR
Original site: A0A158QWF4_NIPBR 
ID   A0A158QWF4_NIPBR        Unreviewed;      1609 AA.
AC   A0A158QWF4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE            EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN   ORFNames=NBR_LOCUS67 {ECO:0000313|EMBL:VDL61934.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Trichostrongyloidea; Heligmonellidae; Nippostrongylinae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000006601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0000006601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL61934.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000256|RuleBase:RU004279}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC         ECO:0000256|RuleBase:RU004279};
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC       {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
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DR   EMBL; UYSL01000011; VDL61934.1; -; Genomic_DNA.
DR   STRING; 27835.A0A158QWF4; -.
DR   WBParaSite; NBR_0000006601-mRNA-1; NBR_0000006601-mRNA-1; NBR_0000006601.
DR   OMA; PGIMAHF; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   CDD; cd01435; RNAP_I_RPA1_N; 1.
DR   Gene3D; 1.10.132.30; -; 1.
DR   Gene3D; 2.40.40.20; -; 1.
DR   Gene3D; 3.30.70.2850; -; 1.
DR   Gene3D; 6.10.250.2940; -; 1.
DR   Gene3D; 6.20.50.80; -; 1.
DR   Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR   Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR   Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR   InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR   InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR   InterPro; IPR000722; RNA_pol_asu.
DR   InterPro; IPR006592; RNA_pol_N.
DR   InterPro; IPR007080; RNA_pol_Rpb1_1.
DR   InterPro; IPR007066; RNA_pol_Rpb1_3.
DR   InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR   InterPro; IPR007083; RNA_pol_Rpb1_4.
DR   InterPro; IPR007081; RNA_pol_Rpb1_5.
DR   InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR   InterPro; IPR038120; Rpb1_funnel_sf.
DR   PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR   PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR   Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR   Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR   Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR   Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR   Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR   SMART; SM00663; RPOLA_N; 1.
DR   SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW   ECO:0000256|RuleBase:RU004279};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004279};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT   DOMAIN          350..681
FT                   /note="RNA polymerase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00663"
FT   REGION          1311..1416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1333..1381
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1382..1409
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1609 AA;  181667 MW;  95185CDFB5301CF7 CRC64;
     MDGLTTIRSG DEPYMQFDKL KLRNYFPHEI EKLSVLRIVQ TRSFDEIGHA IRGGLYDPLL
     GPVEPRDRCE TCNQYEVYCP GHFGHIRLDV PVFNPMLYSF CFNLLKGSCV QCHRFTCGTD
     GLATKVLLAQ LRCFELGVPH LAPEIETQFK EKLGSSLQSV FLNEEEELQM FAELDKLISD
     RAGRPLSSLT AETPTKNTVD LRKNIIKNYL KNHLFKRKAR CPLCKAFNGQ LRNDGARCVL
     IDFTVHGKKR KKLDIYKSGF EGEEEEEEVR SSDDEKEKKS ALINDTGYGT VEVSESALEI
     QMRAVQSGAC EKLAWRAAEI REHFRLLYKT EGKLLLKLFP MLAGDLCPLD GLFCELIMVP
     PTKFRPIRLF KGERYENPQT VNLRKVLEAT ETIKAVSLVL NGDKSPQLLE LIANRTQGKT
     MNAKMHNAYL ALQQRVNAIY DEELDKHDQN RIPGIKQILE KKQGLFRMNM MGKRVNFACR
     SVITPDPYLD IDEIGIPEIF AKKLTFTEPV NLFNKGHMRK VVRNGPNVHP GANFVMGNKK
     QMLQPDDAAE DARAKRIALS KHLEPANTDN LRPPVKVLRH LRNGDMMMMN RQPSLHKPSI
     QGHRARVITG QRALRMNYAP CKAYNADFDG DEMNGHLVQS HIAQCEVAEL ANVGSNFLVP
     KDATPLLGLI QDHVVSGVLL TIRGRFLTKE DFMHLVLSAF AYRTKRIDIP PPAMIKPCQM
     WSGKQVISCI IKNCVPKGKP LINLTSKAKT PLSCWKVRGF NAPQQNMSES EVVFRQGELL
     VGVLDKQHYG ATQYGLVHSC FELYGHKVGV QILSCFSRLF TTYLQLHGFT LGVADILVRK
     DADKLRKQAI RESRTIGDQV VRNAFGLDDN VSHAEINRIL ASTYCNPRGQ GQDVKMLDYS
     MKQSIAKYND AITKACVPDG LIRQFPENAL QVMILSGAKG SAVNAIQISC CLGQIELEGK
     RMAVTVAGRT LPSFRAYDPS PRAGGYIDQR FLTGINPQEL FFHTMAGREG LIDTAVKTSR
     SGYLQRCLIK HLEGIRVHYD GTVRDHDGSV VQFRYGEDGL DVLKSTYISP KTFPFLKDNL
     DAVTHCSKPE EARDSEYGVD GAEKQYRKIV KWRKKAGADG RPAKKEYRSG FTEFSIDQTG
     VDKKRMVGMW AEMDEAERMV YEKRAPRKCP HAVDEEFNVN STLGALPEKT LDAIHKFSGE
     NDRLRRSLFW KGMRSLVEPG ENVGLLAAQS IGEPSTQMTL NTFHFAGRGE MNVTLGIPRL
     REILMTASDH IATPSAKIER RFLRALANAI TKKYSDVLEY QQVQHRKLRA GNLSAGLGQR
     NAGAPTRRAQ NMDDGNSSDE EAAGGREADA AEQRLHNRHR DDAAEYEGEE EDRVHVEKDD
     DDEQNEIGEA NEEGSEKEND DEDEEEEDEK DVTVPKKSAD ERIKYVISQS TLIVDYKYDV
     KSERWCEVVF QLPLGNKSKE VERFIVHQTP GIERCIETEE TVRDVPTKFL QTQGINLEEA
     LHGDTDFEEV EEFKASVDEV EDVVWTPEDD SVCDHIDDPS EKAIVRDGRT ITSSMAFFKH
     ADVLDVNAIY SNDLNLILHQ YGVEACSRAI VQVSWAVTYF DASHKECFF
//
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