ID   A0A158QYQ3_NIPBR        Unreviewed;       785 AA.
AC   A0A158QYQ3;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN   ORFNames=NBR_LOCUS8837 {ECO:0000313|EMBL:VDL72426.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000883601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0000883601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL72426.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001436};
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DR   EMBL; UYSL01020057; VDL72426.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158QYQ3; -.
DR   STRING; 27835.A0A158QYQ3; -.
DR   WBParaSite; NBR_0000883601-mRNA-1; NBR_0000883601-mRNA-1; NBR_0000883601.
DR   OMA; TKVQCRL; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06352; PBP1_NPR_GC-like; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   PANTHER; PTHR11920:SF498; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-8; 1.
DR   Pfam; PF01094; ANF_receptor; 2.
DR   Pfam; PF00211; Guanylate_cyc; 2.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        297..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        470..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          227..553
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          623..718
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   COILED          560..587
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   785 AA;  88321 MW;  C420B58B7ABE5491 CRC64;
     MYHLQKVKVF IGPYCNAEMD AVARMAAFWN IPIIGYMAAS NSLSDKKAYP TLARVSLRTT
     NSIAEATCAL LRHYGWYKIV FDEWADAKAM LASESSREFL TAANSQGMAV NEYAYVLPWL
     QDGAKDTSPW IAADGSILQK VKDQYANTII VDDVNSFDNS IIQPFLERIK EAGLSEADVD
     IANIYGYLYL FDSLKLYAIA AKKVMNETGG VKNVVNGRLV WNTMRRLRFS GMLGSSGIAS
     GVVTMDDRGE RAPLYRGFFV SPNSEQVLPM VHLEPTMIKD CDGDEPSCGF RGERCDFTLV
     IVGGVLVILL LLAMASIYFI RRLIEKRALD KLPFRIYRDD IQFIDEEQLK SMMKQAIHDN
     INPFLGIAFN EKEEVLILGL EYLHASAIGY HGALSTWSCL IDRNWMIKLT DYGIADPLER
     WEKQQAISVD GLKDGDDKTQ ALQATSALYE APEMLKNREK NRLRRNRKQL ADIYAFGVVM
     YEIFFRALPF PEGTDISELV EAIKDGSKVV KPTIQKNKVL NMDLTNLIED CWNGSPEMRP
     SLRRIKLNVE TYLKVRGSLV DQMMRMMEEY ANNLERTVQE RTGMLEEANV RADKLLSQLL
     PAYVASELKQ GRSVPPKMFS SATILFSDIV GFADLCQSAT PLEVVNVLNG VFDGFDQFIA
     RRDAYKYLTD FAVPHKPRER IVCRLGFHTG PVAAAVVGLN APRYCLFGDT VNMSSRMESN
     SEPGKTQISE AANKLLLEHY PDYETEERGQ ISVKGKGMCT TYWLLGVKQT SSNTYQAPTS
     QVKQT
//