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Database: UniProt
Entry: A0A158R2T8_NIPBR
LinkDB: A0A158R2T8_NIPBR
Original site: A0A158R2T8_NIPBR 
ID   A0A158R2T8_NIPBR        Unreviewed;       816 AA.
AC   A0A158R2T8;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   15-FEB-2017, entry version 4.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Heligmonellidae; Nippostrongylinae;
OC   Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|WBParaSite:NBR_0001682201-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001682201-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:NBR_0001682201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; NBR_0001682201-mRNA-1; NBR_0001682201-mRNA-1; NBR_0001682201.
DR   Proteomes; UP000038043; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038043};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038043};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    341    365       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    386    404       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    484    504       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    516    541       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    619    642       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    747    771       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       36     63       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   816 AA;  93279 MW;  2BFB2A72B0FACEA7 CRC64;
     MERKLRFLES QITKDNIQIA GRLDQGDYSV MPTAELNQLE ATLADLERDV KNMNESDAQL
     KKNYMELKEW DAVLEKTDEF FQGGVDDQAA EELEVQEEEY GKGEKAPISY VVGVIERSRL
     LVFERVLWRA SHHTAYLRSA AIDEDLEDEN REKVQKAVFI VFYKGDRLRS IVEKVCDGFK
     AKLMKNCPKT FKDRQSARND VRARLQDVKT VLGQTTEHRF RVLQAAANNH NAWLRQVRMQ
     KTVYHHLNLF TFDGIGRFFV AECWVPMVHL DEVKAALERG AEISGSTVQP VLNILDTPEE
     PPTYNRTNKF TAVFQGIVDS YGIASYRELN PAPFTIISFP FIFSCMFGDL GHGILMFLAG
     LYFVLRERNL IERNIRDEIF GMFFGGRYII LLMGLFSIYA GVIYNDMFAK SFNIFGTTWL
     NPYQQDEILT WINQSIDAKK EMLIEINPEY SYQHAGGPYL YGVDPIWNLA ENKLNFLNSM
     KMKLSVIAGI TQMTFGVILS FFNYRFFKAK IDIFTVFIPQ MLFMACIFIY LCLQIVLKWI
     FFWVKAEDIF GQLYPGSHCA PSLLIGLINM FMFKDREPGF VQLDKPIAGT GVDGIPQQFQ
     EQEGCYLTQW YPGQSTIEAI LVLIAVLCIP VMLFGKPIHF ILEQRKKRKA MGSNISVRAN
     VVSDDSEIII NGHNKKEESE PSSGHGHDES FGDIMVHQSI HTIEYVLGCV SHTASYLRLW
     ALSLAHAQLS EVLWHMVLVQ AFGLDGVAGV IATYVIFFFF AVLTFSILVL MEGLSAFLHA
     LRLHWVEFQS KFYLGLGYAF VPYSFKTALQ AAELGN
//
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