ID   A0A158R4D9_9BILA        Unreviewed;       708 AA.
AC   A0A158R4D9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
OS   Syphacia muris.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX   NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000313001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMUV_0000313001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A158R4D9; -.
DR   STRING; 451379.A0A158R4D9; -.
DR   WBParaSite; SMUV_0000313001-mRNA-1; SMUV_0000313001-mRNA-1; SMUV_0000313001.
DR   Proteomes; UP000046393; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..708
FT                   /note="Nicastrin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007631526"
FT   TRANSMEM        664..685
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          36..209
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   708 AA;  79872 MW;  8BE6644602FD92C3 CRC64;
     MYAGLFIIIN ICVFLLSEAR LLEQIYVNFN DVSENCYLIL NGTHQFGCQS SLSGNSGVVA
     YYYDDNSDKN IEAKFDASVK LIVAIDLFIF NELKLLKAIR FLKQKRVNGV LLLVNNQSLT
     LDMPLSEDST CPNQAYSLYG NKCEKKWNSA GALTPNGFRF TDFKKPIFLV KNETISRIIT
     KHCYEKFNRN GTLPGKSLCS ARLSSHMSAA GSAEICMRRN EQSVTLTEIP NIFCSALTDY
     NIISINPPLA IKNKPQRFMF IATRMDSFSS FSYNVLGESS VLKSIISIIA VTEVIGRNIK
     MYETLAKSSN RALVFAFFHG ESLDYIGSGR TVFDMLNNEF PVKIESLTPD IHTMNISDVD
     AFLEVQIISR SNSFTAHVDG QSYLKFSRRN VNEFINAAQK ALFLDGYKMQ LHLMSNISSD
     TQLPPSSLQM FLAKQRNISG LLLASFNESY GYKKLNSFGD LLNVKDKAAD IEQISAAATA
     ALGAALQYVY GDKSLNAFFQ IDKKFVNKLY DCFISAPDWE TCSLFQEILK ENREFSSLSA
     FSRKLKETSI GVDRQTSVIR VIVQALLVYT LGSKDLVNVN TPEQCSDLNG NAQLYYHTWQ
     RDPDKNSSIC YRNSMYITPA KSPAFDIDDY DYKSGMYPTW VESQWDVPEL VLFLSPPHSI
     KFDLLIFIFG CIWFMFSYAF TEVVYRSNKH FFDPSAPPPE ADQTAAPL
//