ID A0A160FEU0_9BACI Unreviewed; 854 AA.
AC A0A160FEU0;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:ANB65195.1};
GN ORFNames=GFC29_479 {ECO:0000313|EMBL:ANB65195.1};
OS Anoxybacillus sp. B7M1.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Anoxybacillus.
OX NCBI_TaxID=1490057 {ECO:0000313|EMBL:ANB65195.1, ECO:0000313|Proteomes:UP000076753};
RN [1] {ECO:0000313|EMBL:ANB65195.1, ECO:0000313|Proteomes:UP000076753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=b7m1 {ECO:0000313|Proteomes:UP000076753};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP015436; ANB65195.1; -; Genomic_DNA.
DR RefSeq; WP_044746062.1; NZ_CP015436.1.
DR AlphaFoldDB; A0A160FEU0; -.
DR KEGG; anl:GFC29_479; -.
DR PATRIC; fig|1490057.3.peg.530; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000076753; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000076753}.
FT DOMAIN 680..696
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 490..517
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 606..613
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 854 AA; 98238 MW; 86C7CB9D5FAD1F6F CRC64;
MATYTPMIQQ YLQIKAQYPD AFLFFRLGDF YEMFFEDAVK AAQELEITLT SRDGGAEERI
PMCGVPYHSA QGYIEQLIEK GYKVAICEQV EDPKTAKGVV RREVVQLITP GTVMEGKRLL
EKENNYLATV SAFQDGTYGL AYMDLSTGEN RVTLLHSWEE VMNELYAIGA KEIVISPDFP
ETLRQLLKER YDMTVSEEEN TVLPEAFFTV AAALEQDKLK MTFARLVHYI VRTQKRSLDH
LQPAQVYQVD QYMKMDVYSK RNLELTETIR SKGRKGSLLW LLDETVTAMG GRLLKQWLDR
PLLDREVIEW RFSIVETLLQ QYFERQELRT LLREVYDLER LAGRVAYGNV NARDFVQLKK
SLQQIPALKE VVQRLNHQEA EQLAERLDPC FELVELLERA IQEQPPLSVK EGNIIKDGYN
ETLDRFRDAS RNGKTWIAQL ESKEREITGI KSLKIGYNRV FGYYIEVTKA NLHLLPEGRY
ERKQTLANAE RFVTQELKEK EALILEAEEK SMELEYELFV QIREQVKQFI PRLQMLAKMI
SQLDVLQSFA TVSEERHYVR PRFSHERELW IQAGRHPVVE KVLGSQTYVP NDCMMNRERE
LLLITGPNMS GKSTYMRQVA LTAIMAQIGC FVPADQAVLP IFDQVFTRIG AADDLVSGQS
TFMVEMLEAR NAIVHATQNS LILFDEIGRG TSTYDGMALA QAIIEYVHHK IGAKTLFSTH
YHELTVLEQA LPRLKNVHVR AIEEDGKVVF LHKIEDGPAD QSYGIHVAEL AELPAELIQR
AKEILAELEQ PGQEKTKPFE QLSLFAEEAP AKSKDASLSK KEKEVIRLLE SLNLLDMTPL
QALNQLYEIQ KMLR
//
