ID A0A160IIN1_9BACI Unreviewed; 728 AA.
AC A0A160IIN1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=ABE65_003040 {ECO:0000313|EMBL:ANC75843.1};
OS Fictibacillus phosphorivorans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Fictibacillus.
OX NCBI_TaxID=1221500 {ECO:0000313|EMBL:ANC75843.1, ECO:0000313|Proteomes:UP000076623};
RN [1] {ECO:0000313|EMBL:ANC75843.1, ECO:0000313|Proteomes:UP000076623}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G25-29 {ECO:0000313|EMBL:ANC75843.1,
RC ECO:0000313|Proteomes:UP000076623};
RA Zheng Z.;
RT "Complete genome sequence of Fictibacillus phosphorivorans G25-29, a strain
RT toxic to nematodes.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP015378; ANC75843.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A160IIN1; -.
DR STRING; 1221500.ABE65_003040; -.
DR KEGG; fpn:ABE65_003040; -.
DR Proteomes; UP000076623; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 14..307
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 308..570
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT COILED 524..554
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 35..42
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 728 AA; 84234 MW; B98C92A2F5A89ACA CRC64;
MGDFFTKMKN DLGITLNEVQ KKAVMKTEGP LLLLASPGSG KTTTIIMRIG YLIMEKGIQP
SRIKAVTFSK ASANDMKERF TRFYPELPAV DFSTIHSFAF EVVRDHYRKL GLPFTIIEGE
SDSGEKEGSA GNFQHNKKMM LRHLFKSLVG ENITEDQMDE LTTYISYIKN KMIPIERWSE
VSCDVPQAEE IFKQYEELKR SDQHHVLLDF DDMLTIGNDV LENHAHVLRY YQNRYDYFLT
DESQDTSLVQ HSIIEKMVST HRNLCVVADD DQSIYSWRGA EPSYLLKFKE KYSDASILFM
EQNYRSSEDI VTVANSFIKR NKNRYEKNMF TQNPSHQPVE VKQLVNFKEQ SKYLVSELSD
AIHLKEIAIL YRNNSSSIGL MNDFDRSGIP FYMKDADNRF FSHWVVQDIL NFMRMAFTDK
RPDILEKIHL KFNGYITKQQ MQALKQLNHN DSVFDNLLNH VKLQEYQVKL LKASKETFKE
MKEMKPLQAI RVIRDRLGYD KAIEKISKSL GFRMDYLVGI LNTLEEIATD LESLEEFAKR
LKHLEVVLKT AKKKKGHDAI TLSTFHSAKG LEFNKVFMID VVDGIIPSSE DRSDHLLLEE
AARLFYVGMT RAKKQLTLVT YPYRDGKKVE ESVFVSDVKN ILDPTRIMKS EPVKKNVKKI
NGVPYNPYSI KKKEELYVGL AVTHRVFGTG EITEISGEFI TFKFQSKEKK LSISACLEMG
LLEPLIHT
//
