ID A0A160JIK5_9PROT Unreviewed; 312 AA.
AC A0A160JIK5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:ANC92950.1};
GN ORFNames=A6A40_14320 {ECO:0000313|EMBL:ANC92950.1};
OS Azospirillum humicireducens.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Azospirillaceae; Azospirillum.
OX NCBI_TaxID=1226968 {ECO:0000313|EMBL:ANC92950.1, ECO:0000313|Proteomes:UP000077405};
RN [1] {ECO:0000313|EMBL:ANC92950.1, ECO:0000313|Proteomes:UP000077405}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SgZ-5 {ECO:0000313|EMBL:ANC92950.1,
RC ECO:0000313|Proteomes:UP000077405};
RX PubMed=23264502; DOI=10.1099/ijs.0.046813-0;
RA Zhou S., Han L., Wang Y., Yang G., Zhuang L., Hu P.;
RT "Azospirillum humicireducens sp. nov., a nitrogen-fixing bacterium isolated
RT from a microbial fuel cell.";
RL Int. J. Syst. Evol. Microbiol. 63:2618-2624(2013).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP015285; ANC92950.1; -; Genomic_DNA.
DR RefSeq; WP_063635990.1; NZ_CP015285.1.
DR AlphaFoldDB; A0A160JIK5; -.
DR STRING; 1226968.A6A40_14320; -.
DR KEGG; ahu:A6A40_14320; -.
DR OrthoDB; 9793626at2; -.
DR Proteomes; UP000077405; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12156; HPPR; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 5..311
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 108..280
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 312 AA; 32708 MW; BB9AC2115F1C835B CRC64;
MKPEILLVEP MMPAIEQALD AAYTVHRLSA APDRGRLIAE LADRVRAVVT GGGTGVKNTV
VDALPKLGIV AINGVGTDAV DLEHCRGRGV RVTNTPDVLT DDVADLAIGL LIAASRRMTV
GDRFVRAGRW PTGKLPLARK VSGKRLGILG LGRIGEAIAK RAEAFGMTIA YTNRKPRDGV
PYRFVASPVD LARESDMLVV AASAGPDARN MVGRAVLDAL GPDGILVNVA RGSVVDEPEL
LAALTEGRLG GAGLDVFADE PNVPEGFHGL DTVVLQPHQA SATVETRTAM GQLVLDNLDA
FFAGRPLPTA VV
//
