ID   A0A161LKT1_9ACTN        Unreviewed;       761 AA.
AC   A0A161LKT1;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Peptidase {ECO:0000313|EMBL:GAT67435.1};
GN   ORFNames=PS9374_03089 {ECO:0000313|EMBL:GAT67435.1};
OS   Planomonospora sphaerica.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Planomonospora.
OX   NCBI_TaxID=161355 {ECO:0000313|EMBL:GAT67435.1, ECO:0000313|Proteomes:UP000077701};
RN   [1] {ECO:0000313|EMBL:GAT67435.1, ECO:0000313|Proteomes:UP000077701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 9374 {ECO:0000313|EMBL:GAT67435.1,
RC   ECO:0000313|Proteomes:UP000077701};
RA   Dohra H., Suzuki T., Inoue Y., Kodani S.;
RT   "Draft Genome Sequence of Planomonospora sphaerica JCM9374, a Rare
RT   Actinomycete.";
RL   Genome Announc. 4:e00779-16(2016).
RN   [2] {ECO:0000313|Proteomes:UP000077701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 9374 {ECO:0000313|Proteomes:UP000077701};
RA   Suzuki T., Dohra H., Kodani S.;
RT   "Planomonospora sphaerica JCM9374 whole genome shotgun sequence.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M4 family.
CC       {ECO:0000256|ARBA:ARBA00009388}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAT67435.1}.
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DR   EMBL; BDCX01000007; GAT67435.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A161LKT1; -.
DR   STRING; 161355.PS9374_03089; -.
DR   OrthoDB; 345880at2; -.
DR   Proteomes; UP000077701; Unassembled WGS sequence.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd09597; M4_TLP; 1.
DR   Gene3D; 2.60.120.380; -; 1.
DR   Gene3D; 3.10.170.10; -; 1.
DR   Gene3D; 3.10.450.40; -; 1.
DR   Gene3D; 3.10.450.490; -; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR011096; FTP_domain.
DR   InterPro; IPR023612; Peptidase_M4.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   InterPro; IPR001570; Peptidase_M4_C_domain.
DR   InterPro; IPR013856; Peptidase_M4_domain.
DR   PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR   PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR   Pfam; PF07504; FTP; 1.
DR   Pfam; PF01447; Peptidase_M4; 1.
DR   Pfam; PF02868; Peptidase_M4_C; 1.
DR   PRINTS; PR00730; THERMOLYSIN.
DR   SUPFAM; SSF89260; Collagen-binding domain; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077701};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..761
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007823891"
FT   DOMAIN          63..106
FT                   /note="FTP"
FT                   /evidence="ECO:0000259|Pfam:PF07504"
FT   DOMAIN          219..363
FT                   /note="Peptidase M4"
FT                   /evidence="ECO:0000259|Pfam:PF01447"
FT   DOMAIN          366..544
FT                   /note="Peptidase M4 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02868"
FT   ACT_SITE        356
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT   ACT_SITE        443
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ   SEQUENCE   761 AA;  77919 MW;  4DBB9945BDF3EE61 CRC64;
     MRGSLRTPAL AGVAITLAAA TVLAASTSAS ADPPPSPADA AAVARAEQAI ERHRDAIRGA
     GQDDYKVQTV RVDADGTSHV RYHRTYRGLR VRGGDFVVHL RPDGAFADAS VGLTEALTLG
     TSPKVSAATA AGKAKSAFTG KITGVGDPEL FVDASSGQGR LAWETVVSGW AADGQTPSRL
     HVIVDAGSGE VTDSYDEIRS AVEGATTATA STSNALVDGT GNSIYSGTVT ISTTQSGSSY
     SMVDPDRGNG RTCDMNNRTS GTCSTFTDPD NTWGTGSNGN RQSAGVDAHH GAAKTFDYFK
     NVHGRNGIFG NGSGVPSRVH YGSNYVNAFW DGSQMTYGDG SGNSRPLVAI DVAGHEMSHG
     VTENTAGLVY SGESGGLNEA TSDIFGNMVE FYANSSADPG DYQVGEKIDI RGNGTPLRYM
     YDPALDGSSH SCWSTRTASV DVHYSSGVGN HFFFDLAEGT GATPYGTSPV CGSAPAVTGI
     GREKAEKIWF RALDAYFTSS TRYVNSGNPA NTARAYTLRA ATDLYGSCST EYRTVQAAWT
     AVNVAGSDAP CSSGNDFSVS VSPTSASTAP GGSVTTTVST QVTGGSAQTV ALSAAGLPSG
     ATASFDPSSV QAGGTARLTV ATAASTPAGT YPVTVTGTGA TATRTATFTL TVNGPGGGAC
     QGFETTKTGT LSSGASQYQP DGGSFQTTVS GAHRACLDGP NGTDFDLYLQ KRGTFGWSTV
     ARSTSTGPDE SLTYNGTAGT YRYRVHSYSG SGDYTLGYDA P
//