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Database: UniProt
Entry: A0A161QJ79_9BACT
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ID   A0A161QJ79_9BACT        Unreviewed;       450 AA.
AC   A0A161QJ79;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   25-OCT-2017, entry version 11.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AO396_07970 {ECO:0000313|EMBL:KZD19944.1};
OS   candidate division Hyd24-12 bacterium Vib_1.
OC   Bacteria; candidate division Hyd24-12.
OX   NCBI_TaxID=1729715 {ECO:0000313|EMBL:KZD19944.1, ECO:0000313|Proteomes:UP000076781};
RN   [1] {ECO:0000313|EMBL:KZD19944.1, ECO:0000313|Proteomes:UP000076781}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Vib_1 {ECO:0000313|EMBL:KZD19944.1};
RX   PubMed=27058503;
RA   Kirkegaard R.H., Dueholm M.S., McIlroy S.J., Nierychlo M., Karst S.M.,
RA   Albertsen M., Nielsen P.H.;
RT   "Genomic insights into members of the candidate phylum Hyd24-12 common
RT   in mesophilic anaerobic digesters.";
RL   ISME J. 0:0-0(2016).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KZD19944.1}.
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DR   EMBL; LKHD01000011; KZD19944.1; -; Genomic_DNA.
DR   EnsemblBacteria; KZD19944; KZD19944; AO396_07970.
DR   Proteomes; UP000076781; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000076781};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076781}.
FT   DOMAIN      147    279       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      358    427       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     155    162       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   450 AA;  50488 MW;  092F23C1B1B435B8 CRC64;
     MLSDPPGLWT RCLDRARTTM PQSTFTTWLS KSFFESLEED SFIVRFPNQF MANFVMTNHG
     EMLQGSLREL SGHPGLSLLC VGDPAPPFAP SMPAQPPPAP VRQVHSPSIR SNYLHPSYTF
     DRFVAGPSNE LAHAGARAVA MNPGSPSYNP LFIYGGVGLG KTHLIQGIAH EVKRIHPDKR
     FVYVSSEQFL HLFVTSLGRQ NVDEFRRIYR DIDLLLMDDV QFLGGKTQTQ EELFHRFNDL
     YQTGRQIVFT SDRLPGEITG LEERLVSRFQ SGLVADIQPP DYETRMAILE LKVRDEGEFF
     PSEVLDFIAS TIRSNVRQLE GAVHRLAASS RINGAPIDLT LTKRVLTDAF GSSAQRLSAG
     SITAAVAEAF AVSPSQLRGK QRRRDILIPR QVAMFLIREM TESSLVEIGR FFSGRDHSTV
     LNSIDRIRQL SSEDPSLRRR ILDLRTRLSG
//
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