ID A0A162NSW5_9CRUS Unreviewed; 908 AA.
AC A0A162NSW5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Neuronal PAS domain-containing protein {ECO:0000313|EMBL:KZS18239.1};
GN ORFNames=APZ42_015653 {ECO:0000313|EMBL:KZS18239.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:KZS18239.1, ECO:0000313|Proteomes:UP000076858};
RN [1] {ECO:0000313|EMBL:KZS18239.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS18239.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS18239.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZS18239.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LRGB01000547; KZS18239.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A162NSW5; -.
DR STRING; 35525.A0A162NSW5; -.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd19735; bHLH-PAS_dCLOCK; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF3; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..110
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 134..197
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 332..368
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 420..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 100361 MW; 57C7B5AD1C1B2F8A CRC64;
MSVKSQPGGL SSSKLRKATT SKISEYLLGI VLYFVFYTLS VYRNFCSDGL EEEMDEKGVI
KRKSRNLSEK KRRDQFNILI NELCSMVCTG KRKMDKSTIL KSAISFIRNH NQATMQSNCQ
EAVQEDWKPS FLSNEEFTHL MLEALDEFII VFSSTGKILY VSENITCLLG HSPNDLIGSS
LSDLVWEEEK IVVESLLGSW GAEHENSQGG GNKENHISLS CHLRRGNVVD SNAEGSSYEL
VFFSGYYRVQ GNPDISSMSR VSSSWGEDSK ESTNFGDALS QYNGLVFVAS ARLQTPQLSV
EMSIVDVSKS EFTSRHSLEW KFLFLDHRGP PIIGYLPFEV LGTSGYDYYH VDDLEKVSTC
HEALMQKGEV TSCCYRFLTK GQQWIWLQTK YYITYHQWYS KPEFIVCSHR VISHSQVNGR
TLRAESGEGD RIPSTANVSK PLKSEKVGSY LGKNAKSDDR NVFQEDTKRH PKRNAFGNQS
NRDRIKSNRH AFTQNLRQQQ THSSTSDLQP PESPSGESTI LRPPPLPIAE SMSQHVRHPS
GSSRVGTALS DAGSISSSGS FQSAASMQSD QSMHSIHSHS SMQSVHGQQA HQGTSSFRST
NQSCSVHSCV NTNHNHQNKQ SEALFLSQHG ISSANSMQIS NSNQQIHTQS RMGEVQSNFS
PSTPISSATI SNAGHRFLQP RVNSGSSVRR VFSPGSVPAT VTSANPVSSS GPSFTYQSVA
IGMDTSGVTV PVQRIIEGLP VVTLPGIVTH EPIVMTAAQR EFHERLKMKH LEIQKSILAQ
QEELRRVETE LLLAQYGAWG PTVLKMTVPY ADNDGTSSAT QQTVLSTGEL VTCYTTENTI
PAGQPSSAQV GNSGTGQMTF SPGTPILVQS PPEMHARSPE RDFLSHEIQI LLAQSLLQDN
TTSTEYLP
//
