ID A0A162TKW9_9CLOT Unreviewed; 399 AA.
AC A0A162TKW9;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Methionine gamma-lyase {ECO:0000313|EMBL:KZL92775.1};
DE EC=4.4.1.11 {ECO:0000313|EMBL:KZL92775.1};
GN Name=mdeA_2 {ECO:0000313|EMBL:KZL92775.1};
GN ORFNames=CLMAG_25890 {ECO:0000313|EMBL:KZL92775.1};
OS Clostridium magnum DSM 2767.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121326 {ECO:0000313|EMBL:KZL92775.1, ECO:0000313|Proteomes:UP000076603};
RN [1] {ECO:0000313|EMBL:KZL92775.1, ECO:0000313|Proteomes:UP000076603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2767 {ECO:0000313|EMBL:KZL92775.1,
RC ECO:0000313|Proteomes:UP000076603};
RA Poehlein A., Uhlig R., Fischer R., Bahl H., Daniel R.;
RT "Genome sequence of Clostridium magnum DSM 2767.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZL92775.1}.
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DR EMBL; LWAE01000002; KZL92775.1; -; Genomic_DNA.
DR RefSeq; WP_066622495.1; NZ_LWAE01000002.1.
DR AlphaFoldDB; A0A162TKW9; -.
DR STRING; 1121326.CLMAG_25890; -.
DR PATRIC; fig|1121326.3.peg.2595; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000076603; Unassembled WGS sequence.
DR GO; GO:0018826; F:methionine gamma-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF90; CYSTATHIONINE GAMMA-LYASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:KZL92775.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000076603}.
FT MOD_RES 212
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 399 AA; 43253 MW; BA03A5830CEE03E3 CRC64;
MDENILNNLG FSTKAIHGGN KKNDVGSAAT PIYQTSTFIF DTAEQGGRIF SGDEVGYRYT
RFGNPTNAVL EEKLALLEGA EACISAASGL GAISTALWTT LKAGDHVISG ETIYGDTSAL
LNNGLKKYGV EIDFVDMANP ENVRKAMKEN TRVVYIETPA NPTLKISDIK AISKIAHKNK
GCIVMVDNTF CTPYIQRPLE LAADVVLHSG TKFLNGHGDV VAGFILGSRE FINEAKLGLQ
KLTGAILSPF DSYLLIRGLK TLPIRMEKHC SNAIAVAEFL EKHPAIDKVY YPGLESFEQY
ELYKSQMNLP GAIIAFELIG GVDSGRALMN NLKLCRLAVS LGDTETLIQH PASMSHSVCS
KEERLAAGIK DGLVRLAIGL EDVEDIIDDL KQALDLLVK
//
