ID A0A162YNG8_MUCCL Unreviewed; 1011 AA.
AC A0A162YNG8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 08-NOV-2023, entry version 26.
DE RecName: Full=Rab-GAP TBC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MUCCIDRAFT_114869 {ECO:0000313|EMBL:OAC99666.1};
OS Mucor lusitanicus CBS 277.49.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=747725 {ECO:0000313|EMBL:OAC99666.1, ECO:0000313|Proteomes:UP000077051};
RN [1] {ECO:0000313|EMBL:OAC99666.1, ECO:0000313|Proteomes:UP000077051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 277.49 {ECO:0000313|EMBL:OAC99666.1,
RC ECO:0000313|Proteomes:UP000077051};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA Mccluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De Vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAC99666.1}.
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DR EMBL; AMYB01000008; OAC99666.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A162YNG8; -.
DR STRING; 747725.A0A162YNG8; -.
DR VEuPathDB; FungiDB:QYA_114869; -.
DR OrthoDB; 122047at2759; -.
DR Proteomes; UP000077051; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00180; PKc; 1.
DR CDD; cd00158; RHOD; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR PANTHER; PTHR22957:SF168; TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR SMART; SM00450; RHOD; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000077051}.
FT DOMAIN 1..294
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 585..770
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 888..967
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT REGION 489..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1011 AA; 113809 MW; E61019235F6055E8 CRC64;
MALFANCIDL AIHQDQRMTK LASVNFVASS RVSEELALSG HLALSAPSQI MGQFQFLKTL
SHPNLCEYVE IHRGKHDRLF VVSEYFDLSL QKARNLDSND PPPVSMTVLK QWAFEILSAL
QFLKENHIIH AALSPTNIML DKENHVKLFG YGLHYMTSGG RDVDFPIGYP TYLAPECLDN
ISSVGFDKRD VWATGVILVE QYTRNSFWTT SDVGLIFDTL MTLREWHQED PSSNIWQHDG
IESLDINKSI LEFLQKQDIQ DKEELGFQKF ITQCLDLSVE KRPGTAEALS GPFFEHGLVP
VDTVAWVEGP ILASDVVEPE TIDTQNSQSQ EDVNGTLQGL PVSQMYNLWK LAGGDVELDL
VKRGVFLSTP VIKRLPRVCM MPEGLEVGDK VTDTAQLYSD AIYVLGFKEL YQRLEEGSKK
VASDKFEWDT DYFILVDEND VNFLLDSEDD DSSTGQGESD TQQDDVLTEA DELAANINDL
MFTDDLLSSE PASLNSNGMP TPTTPSSSRS RALSMNSVMG RSRSASSLSM NSTTSIPNQP
NVPKLPLFLR EQDINYQHYR QTLFSELLRQ YPASRKEILH HAKVDIPPLL RGKVWAAVLG
VRGDVQHEYE QIEKCVDMGA DRQIEVDVPR CHQYNQLLAS STGHEKLRRL LKAWVSVNTK
LVYWQGLDSL CAPFLTLNFN DEAIAFACLQ KFIPKFLNNF FLSDNAPVLQ EYLAVFRHLL
SFHDPELSSH LDTIGFMPDL YAIPWFLTLF THVFPLDKIY HLWDKLLVGP SSLPLFAGIA
ILRQIRDTLL SYEFNDCIVL FSDSFPKVDI EKCVQSALNM CKVTPPSVSS RVHGPDNSDD
NAQEKDSTDA KQLQVKQWWN EPISIETKKA ELAPRLSISD IPKILPYALV LDIRPESEYV
KGHAPSSMNV LASQLSSYAN ILKKLNRKYH VVIANEGEGG PEFAADLVRR NFPRTALLQG
GMDAFETISD KLAHLCTCRP QKQTTAGFKG KGSEPPFVMW RCKVPPPLKK K
//
