ID A0A162ZDB2_PHYB8 Unreviewed; 376 AA.
AC A0A162ZDB2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Isocitrate dehydrogenase NAD-dependent subunit 2 {ECO:0000313|EMBL:OAD66011.1};
GN Name=PbIdh2c {ECO:0000313|EMBL:OAD66011.1};
GN ORFNames=PHYBLDRAFT_42678 {ECO:0000313|EMBL:OAD66011.1};
OS Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC
OS 33097 / NRRL 1555).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Phycomycetaceae; Phycomyces.
OX NCBI_TaxID=763407 {ECO:0000313|EMBL:OAD66011.1, ECO:0000313|Proteomes:UP000077315};
RN [1] {ECO:0000313|Proteomes:UP000077315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1555(-) {ECO:0000313|Proteomes:UP000077315};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA McCluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; KV441006; OAD66011.1; -; Genomic_DNA.
DR RefSeq; XP_018284051.1; XM_018440182.1.
DR AlphaFoldDB; A0A162ZDB2; -.
DR STRING; 763407.A0A162ZDB2; -.
DR GeneID; 29001088; -.
DR VEuPathDB; FungiDB:PHYBL_42678; -.
DR InParanoid; A0A162ZDB2; -.
DR OrthoDB; 143577at2759; -.
DR Proteomes; UP000077315; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF48; HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000077315}.
FT DOMAIN 18..372
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 376 AA; 40534 MW; EF6913F31BC8E4E6 CRC64;
MASNILRRTF ATSSSAIRIG LIPADGIGRE VIPAAQRVLE ALPNGPKFDF VHLDAGFEHF
QKTGTALPQS TVDTLKNECH GALFGAVSSP SHKVAGYSSP IVALRKHLDL YANVRPVISV
KSASTPNQKE LDMLIIRENT ECLYIKSERI EQDPKTGLKV AYADRKISEY ASKRIGAMAF
NMALTRQKLR EQKPLAQRFW KHAPRVTIVH KSNVMSVTDG LFRETVRAVK ESNPELYSGV
DMDEQLVDSM VYRMFREPEA FDVVVAPNLY GDIISDGAAA LVGSLGVVPS ANVGDSFVMG
EPVHGSAPDI AGKGIANPIA AIRSAGLLLE HMGHTAHALA MYDAVNAVLA DASVLTPDLG
GKSSTNDVVE AVLKHL
//
