ID A0A163ATA8_DIDRA Unreviewed; 1076 AA.
AC A0A163ATA8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Calcium-dependent cysteine-type endopeptidase {ECO:0000313|EMBL:KZM21373.1};
GN ORFNames=EKO05_009894 {ECO:0000313|EMBL:KAF9703341.1}, ST47_g7483
GN {ECO:0000313|EMBL:KZM21373.1};
OS Didymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella
OS rabiei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Didymellaceae; Ascochyta.
OX NCBI_TaxID=5454 {ECO:0000313|EMBL:KZM21373.1, ECO:0000313|Proteomes:UP000076837};
RN [1] {ECO:0000313|EMBL:KZM21373.1, ECO:0000313|Proteomes:UP000076837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ArDII {ECO:0000313|EMBL:KZM21373.1,
RC ECO:0000313|Proteomes:UP000076837};
RX PubMed=27091329; DOI=10.1038/srep24638;
RA Verma S., Gazara R.K., Nizam S., Parween S., Chattopadhyay D., Verma P.K.;
RT "Draft genome sequencing and secretome analysis of fungal phytopathogen
RT Ascochyta rabiei provides insight into the necrotrophic effector
RT repertoire.";
RL Sci. Rep. 6:24638-24638(2016).
RN [2] {ECO:0000313|EMBL:KAF9703341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Me14 {ECO:0000313|EMBL:KAF9703341.1};
RA Syme R.A., Farfan-Caceres L., Lichtenzveig J.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF9703341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Me14 {ECO:0000313|EMBL:KAF9703341.1};
RX PubMed=32345704; DOI=10.1534/g3.120.401265;
RA Shah R.M., Williams A.H., Hane J.K., Lawrence J.A., Farfan-Caceres L.M.,
RA Debler J.W., Oliver R.P., Lee R.C.;
RT "Reference Genome Assembly for Australian Ascochyta rabiei Isolate
RT ArME14.";
RL G3 (Bethesda) 10:2131-2140(2020).
RN [4] {ECO:0000313|EMBL:KAF9703341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Me14 {ECO:0000313|EMBL:KAF9703341.1};
RA Shah R.M., Williams A.H., Hane J.K., Lawrence J.A., Farfan-Caceres L.M.,
RA Debler J.W., Oliver R.P., Lee R.C.;
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZM21373.1}.
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DR EMBL; RYYQ01000021; KAF9703341.1; -; Genomic_DNA.
DR EMBL; JYNV01000246; KZM21373.1; -; Genomic_DNA.
DR STRING; 5454.A0A163ATA8; -.
DR OrthoDB; 142935at2759; -.
DR Proteomes; UP000076837; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR Pfam; PF00648; Peptidase_C2; 2.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Reference proteome {ECO:0000313|Proteomes:UP000076837};
KW Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT DOMAIN 161..450
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 190
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 374
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 394
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 1076 AA; 121927 MW; FD10E6AFA216E287 CRC64;
MTMASQVSPN DFINITRPQS RAPSMNGEAF AAASRPRLPV KKQAPQKSID DFWNTFTTKH
PGKIFTILPD NLYAKRAAAH TPKGSIPGKN ALASYEEAVQ SCKTKVAKIV KECRRLNQKY
RDPHFDIEAD FKRSQASPDT PPDCLTSLDK EQSEFQPMSV KRVEDIFENP QFFIEGATAN
DVRQGNDGDC WFMSALATIS NKEELIQRVC VARDEQVGVY GFVFHRDGEW ISEVIDDKLY
LIKEDFDEAK IERYHWLELQ NRKSPDEEYR TVMQTGSRAL YFAQCSDSNE TWLPLLEKAF
AKAHGDYSAI DGGFVGEGIE DLTGGVTSEV FATDILDKDK FWHDELMNVN KTFLFGCGQM
GGIYGARKGI QEKHAYSIME AREIDGQRLL KLRNPWGRTE WTGRWSDGSE EWTPEWMQKL
NHKFGDDGVF WISYRDLLRN YQHFDRTRLF GPEWTVSQQW TSVNVPWSVD YLETKFKVHL
EKPSPVVIVL SQLDDRYYQG LEGQYEFHLQ FRLHKDDEDE YIVRSNGTYY MKRSVSTELD
LEAGNYTVLL KIKATRSPNP TPDEVIRATC TKRREKLLAT GLSYDLAHAK GQFREHEKEK
DRQQREHKSD RKKADARRAH ERERKFRRRQ KLREQKKAAK ETRKLNRPGE MREIEKRLQD
LTGLGIAVEE ENRTEGEEET KPGHPAVTRH RRAASASVVG ERSPSPGGGF QGRGGYNRGR
DGYNAALPGA LQGRGGYNRN EQHGTAMAEA LALQGRGGYQ AANNGFQGRG GYNQNMPGEL
QGRGGYNAEL PGSYQGRDGY NGRDGYNGRD GYNGRDGYNG RDGYNEGQTT ESPVPTPQPT
PQSQPEEFRP GTPGQRTYSP QPDRRSRISP APSRRATLSP IPGVRPAIHI TRGRGTSVSS
LRTRHGTYSP NEISDDSSWD SDLADSLDSE ASDNERDSPR LISQDQIRYY HQNGRSYYTI
EDEDEFERDP WNAVCVIGLR VFSKDADVSI EVQNGGPEKR KDSDAESVAS VSTIRRRQKE
LDVDDSAADA TSPMRTRNNM DEALKGEEKR AAEAELVSHV GTMPAGNELN RQDTLS
//
