ID A0A164JNK2_9NOCA Unreviewed; 427 AA.
AC A0A164JNK2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=glucarate dehydratase {ECO:0000256|ARBA:ARBA00011973};
DE EC=4.2.1.40 {ECO:0000256|ARBA:ARBA00011973};
GN ORFNames=AWN90_39000 {ECO:0000313|EMBL:KZM70574.1};
OS Nocardia terpenica.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=455432 {ECO:0000313|EMBL:KZM70574.1, ECO:0000313|Proteomes:UP000076512};
RN [1] {ECO:0000313|EMBL:KZM70574.1, ECO:0000313|Proteomes:UP000076512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 0406 {ECO:0000313|EMBL:KZM70574.1,
RC ECO:0000313|Proteomes:UP000076512};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O;
CC Xref=Rhea:RHEA:14573, ChEBI:CHEBI:15377, ChEBI:CHEBI:30612,
CC ChEBI:CHEBI:42819; EC=4.2.1.40;
CC Evidence={ECO:0000256|ARBA:ARBA00001426};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005183}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZM70574.1}.
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DR EMBL; LWGR01000013; KZM70574.1; -; Genomic_DNA.
DR RefSeq; WP_067593756.1; NZ_KV411304.1.
DR AlphaFoldDB; A0A164JNK2; -.
DR STRING; 455432.AWN90_39000; -.
DR OrthoDB; 193563at2; -.
DR Proteomes; UP000076512; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR034593; DgoD-like.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR PANTHER; PTHR48080; D-GALACTONATE DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR48080:SF4; GLUCARATE DEHYDRATASE; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDG00055; glucarate_dehydratase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000076512}.
FT DOMAIN 175..269
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 427 AA; 45880 MW; 8C28BB4F66A29AAF CRC64;
MAERLPIITG VRLTPILVSD PPLLNLSGVH QPYTPRLIVE LDTDGGVPGL GETYGDTVYL
ERAAELGPEL VGRSIGAITE IARIGGGEGR LLDAAPAASG LRGALTTDKV RASVVSAFEV
AALDALGRRL GVPVHTLLGG KVRDRVDYCA YLFYKWAEHP GGDGPADDWG AALDPDGVLR
LARKFVRHGG FRSFKLKGGV MAPEEEIAAV RALAAEFPGL PLRLDPNGGW SLRTALRVAA
ELGGIVEYLE DPVATVDGMA QVHRRTGIPL ATNMIVTSMD EVLPAFERDA VQIVLSDHHF
WGGLLATRDL AAVCRVHGRG LSMHSNTHLG ISLAAMTHVA ATVPELNSAC DTHYPWQAED
VVTERFTFTD GAVTVGDAPG LGVDLDRDAV ARLHERWKSL PQWRDRDDVA AMRRADPAYR
PPDSSRF
//
