ID   A0A165AI65_9CRUS        Unreviewed;       810 AA.
AC   A0A165AI65;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=CUB domain-containing protein {ECO:0000259|PROSITE:PS01180};
GN   ORFNames=APZ42_016583 {ECO:0000313|EMBL:KZS17691.1};
OS   Daphnia magna.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX   NCBI_TaxID=35525 {ECO:0000313|EMBL:KZS17691.1, ECO:0000313|Proteomes:UP000076858};
RN   [1] {ECO:0000313|EMBL:KZS17691.1, ECO:0000313|Proteomes:UP000076858}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Xinb3 {ECO:0000313|EMBL:KZS17691.1,
RC   ECO:0000313|Proteomes:UP000076858};
RC   TISSUE=Complete organism {ECO:0000313|EMBL:KZS17691.1};
RA   Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT   "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KZS17691.1}.
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DR   EMBL; LRGB01000626; KZS17691.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A165AI65; -.
DR   STRING; 35525.A0A165AI65; -.
DR   Proteomes; UP000076858; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   CDD; cd00041; CUB; 1.
DR   CDD; cd00112; LDLa; 2.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR   Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR46908:SF4; CUBILIN HOMOLOG; 1.
DR   PANTHER; PTHR46908; CUBILIN-LIKE PROTEIN; 1.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00042; CUB; 1.
DR   SMART; SM00192; LDLa; 2.
DR   SUPFAM; SSF57424; LDL receptor-like module; 2.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR   PROSITE; PS01180; CUB; 1.
DR   PROSITE; PS50068; LDLRA_2; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..810
FT                   /note="CUB domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007855323"
FT   DOMAIN          697..810
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   COILED          34..61
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   DISULFID        401..419
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        413..428
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   810 AA;  90406 MW;  43A6D5E987B99C81 CRC64;
     MGSWDKVVIV FLLTCYTSVQ ADSEKDESSV NQGAECSVTE CEQLRNRIEI LEAAVRGIIS
     AMASQKTGQL ASVNKIMERD IALRTIVSLS STGKDVTKNG TVRYVPVVFN VFRPLLYKNL
     IPCLHHDTIQ VVERDVNTTG KVQASLVKKN ALEITWTPHS TECLKVSSGL WLRIFESNEK
     QLVSPSAEAY LPIPYKCLKK TNSSHSIVLA KQAKGANKGK SCPSEMMISL VQCLAYTVEV
     IPNYQSLKGR LLSTEIVIPP ADDNSTTRNE SLISLVAKSD SLALKWKDNS GCAPRLTAVN
     LKIFPEGKLD AAIVPLSFNV PRSCFQYESE ENVFSLSLSR ANGCPVQLEL NACRKYTLEL
     QSKYQDRFAR PSTLWDTFTA IQESYQQNTE PLNCTADQFW CGSNTKIPHD WVCDGERDCP
     NGQDERYCNH ECNSGFRCGS QCIPINQVCD AKYDCVGGSD ETGENLDFKV VYASFACNEL
     TSHSGHLHDG AIDQQRLQWS KSIFLLSAEN DHTIWLSINS FRTHQNIFLK VYDGPYSNSP
     LLLSHSGSTK PSSVRSSSNK LYLDVPSYSF PGFGVEIFYT TMNNTGQPFV PGCGGYIHED
     GEIFFRNSFS SSVANLTDCV WFVEARESNN TIRLVYDGWD ISGQVLYDER VIPRQARKLA
     VYSISHKTSV QFIMPMNTSG NKTNHWHISS IKAPKHTKMD VAAGSTGTIK SSGFEGYPRD
     IYNDYLWHIV TTPNSTIQLL FAHFRISQAN CMQVYDGPTM RSNVLFEKTG EAAVPFVIRS
     STNELLIRYI SFLGDDVNQT YGFLAVYTTI
//