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Database: UniProt
Entry: A0A165SK86_9GAMM
LinkDB: A0A165SK86_9GAMM
Original site: A0A165SK86_9GAMM 
ID   A0A165SK86_9GAMM        Unreviewed;       529 AA.
AC   A0A165SK86;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=A3709_05885 {ECO:0000313|EMBL:KZX55921.1};
OS   Halioglobus sp. HI00S01.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cellvibrionales;
OC   Halieaceae; Halioglobus.
OX   NCBI_TaxID=1822214 {ECO:0000313|EMBL:KZX55921.1, ECO:0000313|Proteomes:UP000077184};
RN   [1] {ECO:0000313|EMBL:KZX55921.1, ECO:0000313|Proteomes:UP000077184}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI00S01 {ECO:0000313|EMBL:KZX55921.1,
RC   ECO:0000313|Proteomes:UP000077184};
RA   Sosa O.A.;
RT   "Microbial cycling of marine high molecular weight dissolved organic
RT   matter.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KZX55921.1}.
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DR   EMBL; LWEE01000215; KZX55921.1; -; Genomic_DNA.
DR   RefSeq; WP_066056657.1; NZ_LWEE01000215.1.
DR   EnsemblBacteria; KZX55921; KZX55921; A3709_05885.
DR   Proteomes; UP000077184; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077184};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077184}.
FT   DOMAIN      226    431       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      437    506       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     234    241       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   529 AA;  58852 MW;  22E634B6A0F3E427 CRC64;
     MIERRGIGPR FKGIALPGVV WQQCIDRLQD ELPSQQFNTW IRPLEASTDG QSLTLFAPNR
     FIKDFVSDKF ATRIAELVSE LEPSNQLDVV LEIGAGRPVP ERVAVEQPRV ARASMSMSAD
     PVVPASRPQP IQETPAPATP AAFTPPPSSD MAPAVSGFAV SRNPDGVKAA VSEPAQNPAR
     QSEIAGSLQH QNGLVENYTF TNFVEGKSNQ LALAAARQVA ENPGDSYNPL FLYGGVGLGK
     THLMHAVGNA LRQQKPDAKI VYLHSERFVA DMVKALQLNA ISDFKRYYRS VDALLIDDIQ
     FFAKKDRSQE EFFHTFNALL EGGQQMILTC DRYPKEIDGL EERLKSRFGW GLTVAVEPPE
     LETRVAILMK KANQARVDLS PDAAFFIAQR VRSNVRELEG ALKRVIASAH FTGRDIDIDL
     IKDSLKDLLA LQDKQVSLDN IQRTVAEYYK IKVADLMSRR RSRSVARPRQ VAMALAKELT
     NHSLPEIGDS FGGRDHTTVL HACRKIKELR ETNSDIREDY KNLLRSLTT
//
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