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Entry: A0A166B5P3_9EURY
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ID   A0A166B5P3_9EURY        Unreviewed;       551 AA.
AC   A0A166B5P3;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   25-OCT-2017, entry version 9.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   ORFNames=MBORA_10070 {ECO:0000313|EMBL:KZX12896.1};
OS   Methanobrevibacter oralis.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=66851 {ECO:0000313|EMBL:KZX12896.1, ECO:0000313|Proteomes:UP000077428};
RN   [1] {ECO:0000313|EMBL:KZX12896.1, ECO:0000313|Proteomes:UP000077428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7256 {ECO:0000313|EMBL:KZX12896.1,
RC   ECO:0000313|Proteomes:UP000077428};
RA   Poehlein A., Seedorf H., Daniel R.;
RT   "Genome sequence of Methanobrevibacter oralis DSM 7256.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KZX12896.1}.
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DR   EMBL; LWMU01000061; KZX12896.1; -; Genomic_DNA.
DR   RefSeq; WP_042694806.1; NZ_LWMU01000061.1.
DR   EnsemblBacteria; KZX12896; KZX12896; MBORA_10070.
DR   PATRIC; fig|66851.6.peg.1108; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000077428; Unassembled WGS sequence.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000077428};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000077428};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262}.
FT   DOMAIN        6    271       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      318    442       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       150    150       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     260    260       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     274    274       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   551 AA;  60556 MW;  DF51CCADDAE3AD34 CRC64;
     MSSDNKKFLS ALTEKFKGED QKSDHTSFYC FDGWKQSPRK REFNDVAEKL AKERNMPFYN
     PDIGVPLGQR QLMAYKISGT DSYVEGDDLH FCNNAAIQQL VDDIKRTIIV GMDTAHSVLQ
     ERLGVEVTPE TINEYMENIN HALPGGAVVQ EHMVEVHPGL AQDCYAKIFT GNDDLADELD
     KRVLIDINKE FPEDQAEMLK SYIGNKTYQV SRVPTLVVRS CDGGTVSRWS AMQIGMSFIN
     AYKLCAGEAA IADFSYAAKH ADVIGMASFL PARRARGPNE PGGISFGALS DMVQTSRITD
     DPAETTLEVI AAAAAVYDQV WLGSYMSGGV GFTQYASATY TDDILDDFVY YGMDYVEKNY
     GLCGAEKSMD VVRDISTEVT LYGLEQYELP TLLETHFGGS QRASVVSAAA GCSTAFATGN
     SNAGVNGWYL SMILHKEAHS RLGFYGYDLQ DQCGAANSLS IRSDEGLIHE LRGPNYPNYA
     MNVGHQPEYA GIAQAPHAAR GDAFSANPLI KIAFADDNLT FDFKHPRREI AKGALREFMP
     SGERDIIIPS V
//
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