ID A0A166BJA1_9EURY Unreviewed; 326 AA.
AC A0A166BJA1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Homoisocitrate dehydrogenase {ECO:0000313|EMBL:KZX13431.1};
DE EC=1.1.1.87 {ECO:0000313|EMBL:KZX13431.1};
GN Name=hicd_1 {ECO:0000313|EMBL:KZX13431.1};
GN ORFNames=MBCUR_06950 {ECO:0000313|EMBL:KZX13431.1};
OS Methanobrevibacter curvatus.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=49547 {ECO:0000313|EMBL:KZX13431.1, ECO:0000313|Proteomes:UP000077245};
RN [1] {ECO:0000313|EMBL:KZX13431.1, ECO:0000313|Proteomes:UP000077245}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11111 {ECO:0000313|EMBL:KZX13431.1,
RC ECO:0000313|Proteomes:UP000077245};
RA Poehlein A., Seedorf H., Daniel R.;
RT "Genome sequence of Methanobrevibacter curvatus DSM 11111.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZX13431.1}.
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DR EMBL; LWMV01000146; KZX13431.1; -; Genomic_DNA.
DR RefSeq; WP_067090245.1; NZ_LWMV01000146.1.
DR AlphaFoldDB; A0A166BJA1; -.
DR STRING; 49547.MBCUR_06950; -.
DR PATRIC; fig|49547.3.peg.747; -.
DR OrthoDB; 6813at2157; -.
DR Proteomes; UP000077245; Unassembled WGS sequence.
DR GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0047046; F:homoisocitrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR InterPro; IPR011828; LEU3_arc.
DR NCBIfam; TIGR02088; LEU3_arch; 1.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:KZX13431.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077245}.
FT DOMAIN 3..322
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 326 AA; 35215 MW; A289E2F419E7BEAB CRC64;
MYKIAVIPGD GIGKEVMEGA IDVLEGTGVE FSFTYENAGD ECLKDCGYAL PDDTLALAKK
SDAVLFGAAG ETAADVIVRL RQELDLYANL RPVKSYPGTN AIFQDIDFMI VRENTEGMYI
GVESENKDGA TAKRLITHKA SQKICDYAFK YAITTGRKRV TGVHKANVLK ITDGLFKKTF
YEVAEKYDTI ESNDYYVDAT AMYLLTKPQF FDVIVTTNLY GDILSDEGAG IVGGLGLIPS
ANIGDKGALF EPVHGSAPDI AGQSKANPIA MILSAKMMLE FLGENESAKA IDEAVLKVIT
QKNILTPDMG GNSTTKDLAK SIKNNL
//
