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Database: UniProt
Entry: A0A166CWD2_9EURY
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ID   A0A166CWD2_9EURY        Unreviewed;       551 AA.
AC   A0A166CWD2;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   25-OCT-2017, entry version 8.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   ORFNames=MBCUT_02940 {ECO:0000313|EMBL:KZX17247.1};
OS   Methanobrevibacter cuticularis.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=47311 {ECO:0000313|EMBL:KZX17247.1, ECO:0000313|Proteomes:UP000077275};
RN   [1] {ECO:0000313|EMBL:KZX17247.1, ECO:0000313|Proteomes:UP000077275}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11139 {ECO:0000313|EMBL:KZX17247.1,
RC   ECO:0000313|Proteomes:UP000077275};
RA   Poehlein A., Seedorf H., Daniel R.;
RT   "Genome sequence of Methanobrevibacter cuticularis DSM 11139.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KZX17247.1}.
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DR   EMBL; LWMW01000054; KZX17247.1; -; Genomic_DNA.
DR   RefSeq; WP_067257927.1; NZ_LWMW01000054.1.
DR   EnsemblBacteria; KZX17247; KZX17247; MBCUT_02940.
DR   PATRIC; fig|47311.3.peg.324; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000077275; Unassembled WGS sequence.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000077275};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000077275};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262}.
FT   DOMAIN        4    268       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      316    442       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       147    147       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     257    257       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     271    271       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   551 AA;  60678 MW;  A34E0EFC156AFE24 CRC64;
     MANKKFIEAL NKKFKESPEE KTTTFYNLGG WKQSERKSEF AKEGKEIATK RGIPQYNPDV
     GSPLGQRALM PYQVSTTETF VEGDDFHFVN NAAIQQMWDD IRRTVIVGLN TAHTVLEKRL
     GIEVTPETIT EYLETVNHAM PGAAVVQEHM VETNPALVAD SYVKIFTGDD EVADEIDSAF
     VLDINKEFSK EQAEALKAEV GDKIWQVVRI PSIVGRVCDG GTTSRWSAMQ IGMSMISAYN
     QCAGEGATGD FAYASKHAEV IHMGTYLPVR RARAENEPGG IPFGYMADIC QSSRVNEDDP
     VRTTLDVVAM SAALYDQIWL GSYMSGGVGF TQYASAAYTD NVLDDFTYYG KEYVEDKYGG
     LCEAPNNMDT VLDVGSEVTF YGLEQYEEYP ALLETQFGGS QRASVVSAAA GCSTAFATGN
     AQTGLSAWYL SMYLHKEQHS RLGFYGYDLQ DQCGASNVFS IRADEGLPVE MRGPNYPNYA
     MNVGHQGEYA GISQAPHAAR KDAFAFNPLI KIAFADKNLS FDFSQPRAEI AKGALREFMP
     DGERSLIIPA K
//
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