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Database: UniProt
Entry: A0A166VG43_9GAMM
LinkDB: A0A166VG43_9GAMM
Original site: A0A166VG43_9GAMM 
ID   A0A166VG43_9GAMM        Unreviewed;       541 AA.
AC   A0A166VG43;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   05-JUL-2017, entry version 11.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=A3759_10435 {ECO:0000313|EMBL:KZZ45218.1};
OS   Thalassolituus sp. HI0120.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Thalassolituus.
OX   NCBI_TaxID=1822263 {ECO:0000313|EMBL:KZZ45218.1, ECO:0000313|Proteomes:UP000077137};
RN   [1] {ECO:0000313|EMBL:KZZ45218.1, ECO:0000313|Proteomes:UP000077137}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI0120 {ECO:0000313|EMBL:KZZ45218.1,
RC   ECO:0000313|Proteomes:UP000077137};
RA   Sosa O.A.;
RT   "Microbial cycling of marine high molecular weight dissolved organic
RT   matter.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KZZ45218.1}.
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DR   EMBL; LWGC01001396; KZZ45218.1; -; Genomic_DNA.
DR   RefSeq; WP_068657476.1; NZ_LWGC01001396.1.
DR   EnsemblBacteria; KZZ45218; KZZ45218; A3759_10435.
DR   Proteomes; UP000077137; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077137};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077137}.
FT   DOMAIN      238    443       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      449    518       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     246    253       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   541 AA;  60210 MW;  28CDD3E9F2FAB936 CRC64;
     MTGLWQDCLG QLQHELPAQQ YNTWIRPLVA STHDNGQLSL SAPNRFVKDW VKDKYLQRIQ
     EIMSELNGGL ITHVDVVVGE ARPMFQRPQM ASQPQRAPAP RPQSAPAAAA KEEFAFAQPT
     TTAGAGFDAD DFSQVAQTPS MADSAPQQGD LLAADNSSFN TAPSAPSQAP AFAPFNQGNR
     QSAARQPVKP KREVQVEGGL QHQSFLNNNF TFQSFVEGKS NQLAHAAARQ VAENAGGSYN
     PLFIYGGVGL GKTHLMHAVG NYLQSKDPNA KVLYVHSERF VQDMVKALQL NAINEFKRFY
     RGLDALLIDD IQFFAGKERS QEEFFHTFNA LLEGGQQMIL TCDRYPKEIN GLEERLKSRF
     GWGLTVAVEP PELETRVAIL MKKAEQSNVH LPDDAAFFIA QKIRSNVREL EGALKRVIAN
     SHFTGSDITL PFIKESLKDL LALQDKQVSI DNIQRIVAEY YKLKLSDLLS KRRTRSIARP
     RQVAMALSKE LTNHSLPEIG AAFGGRDHTT VLHACRKIKE LQETTADVRE DYKNLLRSLT
     T
//
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