ID   A0A167CCG7_9PEZI        Unreviewed;       343 AA.
AC   A0A167CCG7;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Aldehyde reductase {ECO:0000313|EMBL:KZL82411.1};
GN   ORFNames=CI238_12299 {ECO:0000313|EMBL:KZL82411.1};
OS   Colletotrichum incanum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC   Colletotrichum spaethianum species complex.
OX   NCBI_TaxID=1573173 {ECO:0000313|EMBL:KZL82411.1, ECO:0000313|Proteomes:UP000076584};
RN   [1] {ECO:0000313|EMBL:KZL82411.1, ECO:0000313|Proteomes:UP000076584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MAFF 238704 {ECO:0000313|EMBL:KZL82411.1,
RC   ECO:0000313|Proteomes:UP000076584};
RA   Hacquard S., Kracher B., Hiruma K., Weinman A., Muench P., Garrido Oter R.,
RA   Ver Loren van Themaat E., Dallerey J.-F., Damm U., Henrissat B.,
RA   Lespinet O., Thon M., Kemen E., McHardy A.C., Schulze-Lefert P.,
RA   O'Connell R.J.;
RT   "Survival trade-offs in plant roots during colonization by closely related
RT   pathogenic and mutualistic fungi.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KZL82411.1}.
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DR   EMBL; LFIW01001388; KZL82411.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A167CCG7; -.
DR   STRING; 1573173.A0A167CCG7; -.
DR   Proteomes; UP000076584; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd19071; AKR_AKR1-5-like; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF508; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000076584}.
FT   DOMAIN          49..317
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        76
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         134
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            101
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   343 AA;  38633 MW;  97B11FC9B008B45F CRC64;
     MIVNLIRSCP LPRLHTSLLR RQVRGVASRS VQHELNTGAK IPAIGFGTFQ DPDAQEDAVK
     TALNCGYRHI DTARVYDTEV QVGKGIKASS VPRKEIFLTT KLWCNSHHPE DVEAALDASL
     RDLDTPYVDL FLIHYPCTFA RGEDRFPKDA AGNMVMGKTT FVDTWKAMEA LSKTGKTRAI
     GVSNFSQDEV QTLLDKGSVV PAVHQMELHP YLQQHAFADW QRARGIHMTH FSPLGNQNSF
     YREVSWSKQQ SHMRRIVDHP VLVEVGKKHN KTPVQVALAW GVNSGRSVIP KSVIELQIKE
     NLESDFVLDG EDMDKIATMD LKARFNDPSE EYRWPLYNGL DGV
//