ID A0A167XAW3_9FLAO Unreviewed; 370 AA.
AC A0A167XAW3;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Thiamine biosynthesis protein ThiH {ECO:0000313|EMBL:OAB28174.1};
GN Name=thiH {ECO:0000313|EMBL:OAB28174.1};
GN ORFNames=FBFR_10055 {ECO:0000313|EMBL:OAB28174.1};
OS Flavobacterium fryxellicola.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=249352 {ECO:0000313|EMBL:OAB28174.1, ECO:0000313|Proteomes:UP000077164};
RN [1] {ECO:0000313|EMBL:OAB28174.1, ECO:0000313|Proteomes:UP000077164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16209 {ECO:0000313|EMBL:OAB28174.1,
RC ECO:0000313|Proteomes:UP000077164};
RA Shin S.-K., Yi H.;
RT "Draft genome sequence of Flavobacterium fryxellicola DSM 16209.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAB28174.1}.
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DR EMBL; LVJE01000013; OAB28174.1; -; Genomic_DNA.
DR RefSeq; WP_066080561.1; NZ_LVJE01000013.1.
DR AlphaFoldDB; A0A167XAW3; -.
DR STRING; 249352.SAMN05444395_11224; -.
DR OrthoDB; 9801120at2; -.
DR Proteomes; UP000077164; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00876; BATS; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 71..292
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 370 AA; 42564 MW; CE9DCE4E3504E9A0 CRC64;
MNTFKSVFEN YDWDAIKTKI YQTTAQDVER ALAKKKRNLD DFLALISPVA QNYLEAMAQE
CHELTKKRFG KTIQIYAPLY LSNECQNICT YCGFSLDNKI KRKTLNEAEI TLEVEALKSA
GFDHVLLVTG EANYTVNIHY FLKAIAQIQN DFSIISVEVQ PLSTEEYEQL HAAGVYSVLV
YQETYHQEVY KKYHTKGKKS NFDFRLETPD RIGTAGIHKI GLGVLLGLED WRTDSFFNAL
HLDYLQKTYW QTKYTVSFPR LRPAEGVIEP NFIMDDKDLT QLICAYRLWN EDLEISISTR
ENEKFRDNII PIGITSMSAG SKTNPGGYVV DPQSLEQFEI SDERPAAEIA QVISNSGYEP
VWKDWDKSFK
//
