ID A0A168IAH9_MUCCL Unreviewed; 1071 AA.
AC A0A168IAH9;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MUCCIDRAFT_113189 {ECO:0000313|EMBL:OAC99748.1};
OS Mucor lusitanicus CBS 277.49.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=747725 {ECO:0000313|EMBL:OAC99748.1, ECO:0000313|Proteomes:UP000077051};
RN [1] {ECO:0000313|EMBL:OAC99748.1, ECO:0000313|Proteomes:UP000077051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 277.49 {ECO:0000313|EMBL:OAC99748.1,
RC ECO:0000313|Proteomes:UP000077051};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA Mccluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De Vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAC99748.1}.
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DR EMBL; AMYB01000007; OAC99748.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168IAH9; -.
DR STRING; 747725.A0A168IAH9; -.
DR VEuPathDB; FungiDB:QYA_113189; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000077051; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000077051}.
FT DOMAIN 311..505
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 729..1040
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 616..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1071 AA; 120164 MW; 0D6610B5E53DBF3F CRC64;
MPTLAPATKD IGDSPSLESL YKDLDLYMKE LDKEVAAAAA AAAASQPAAV ATATAPAAPK
VNRHHTAKQP SFSFKIAGVI MDDMDGSSNS STTTATASTA QMSLSEDQCH LDSKDRPSIA
LLSELSRQFV QRVNVLVASR NIFCSTEYPK SFTGEEAVNI LILIIGHDWS RKEYRNLARR
MMQTEAPALF SPIAYSDKSL RNNTLYDSSQ EAYTLNELAE NEALAQSLIV PLMDCYTPYC
TKGVSSGCYA PTCPNRGSQL LMKSNIINRE LQRNISLTSS MASSQDTLVS RCWSNTVSRE
TLQKTPAKEM KRQEAIYELI YTEEDYVRDL NLLDELFAKP LLRAQCIEFD RRKDFCNELF
GNYAEIADIH RSMYRELRDH QLTSQEMGGN IGFVDEIGSI VLRHVDHFMH AYTQYGPHFI
MAEYTAKREA ANNILFHNFI REKEKQAETR KLPFRHFIIL PITRLQRYPL LLDAILKRTT
IESERQTLTE CIDRIKAVAA TVDSLTAEAK KALRIREIND KILFKPNHTP YNLELLSPGR
QLIHEGPLKR RSHLVVESID LHVFLFDHLL LMTKPKKSGS STVEHYVVSK NPIPLNLLVV
NDVAENFIFS TFRSNSTTKG TSASMSSLIP TPTSSSPLTP VSEEPAAAAA ALTPNSQYIN
QSSLNIRHLG RHGGEYILYT ETPSARLIWK QKIIRAQADL VIKQEPDNAF KVSTISDTKF
ALSGSVNNYG KVTCIASFVG SKGAKMVVLG TQQGIWMGKE GDTNGLTRVL MVNDVAQIGV
LEAQNILLVL ADKVLTAYPL VQLDPTSPSY ISPSSTKSAV SFRVLTNHVS FFNSGTCNGR
TLVVTMKRRG PDSHFKAYEP ICGDLNESRN AKFLVTKKSS FMSKPPPAWF KIYKEFYIGT
LSVAVHFLKS KVLVACSRGF EVIDLDHLSE VKPNLPDLEH RDFNFVATSD AKPLNMFKCK
DNFLMCYDRF AFLITTHGDY VRRFKRIDWE GHPHAVAYHY PYVLAFDHKF IEIRHVETGK
LVQVAVGDNT RFLTSSFSNT NTTSPEIFGL ITHPFRTEYQ HIFKLEPLFS S
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