ID A0A168ICZ9_MUCCL Unreviewed; 1754 AA.
AC A0A168ICZ9;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=MUCCIDRAFT_113272 {ECO:0000313|EMBL:OAC99827.1};
OS Mucor lusitanicus CBS 277.49.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=747725 {ECO:0000313|EMBL:OAC99827.1, ECO:0000313|Proteomes:UP000077051};
RN [1] {ECO:0000313|EMBL:OAC99827.1, ECO:0000313|Proteomes:UP000077051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 277.49 {ECO:0000313|EMBL:OAC99827.1,
RC ECO:0000313|Proteomes:UP000077051};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA Mccluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De Vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAC99827.1}.
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DR EMBL; AMYB01000007; OAC99827.1; -; Genomic_DNA.
DR STRING; 747725.A0A168ICZ9; -.
DR VEuPathDB; FungiDB:QYA_113272; -.
DR OrthoDB; 1422944at2759; -.
DR Proteomes; UP000077051; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.40.640; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01017; Arrestin_C; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000077051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 658..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..816
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 859..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 987..1007
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 654..818
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REPEAT 1329..1351
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 390..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1483..1535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1686..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1507..1535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1754 AA; 195713 MW; E3A3CD7A1BBEEC23 CRC64;
MIASSYSALH PSIRSDFHVR PSVMSKRMNM LPNPIQLVQT SDFHINIEND HIILHGNVDE
SAGVMLRGSV VLNCHETTKV RSITLKFIGK AKVNWTEGLG SHQRHYKEEK TIIKHEWSFL
PSNRKTYHLP EGHYKWDFEL PLPGDLPESV EHDLGEVYYR LKAVVERPTF SMNYNDRKML
RVSRVLLPSS LELTQSLVIS NIWVDKLSYD ISVPSKVFSM GSLIPITFAL MPIAQDLQVR
SVSCVLKEYT TLSAEDHSKM EGRVIKHLRD ENFASGPDPW TKTELLPVPD YTSHLIQTDS
LCDLIKIKHK LKFTVSLTNA DGHISELRAA IPVVIAEISP EEDENALPAY EDAWKSAPYD
PQQVAALIAR GDLPPSIAIS APNEAAIGAN TTLSSSDTDD EDHTRPSTPI GNTVAPADGG
LSLPWQGIDL SRVPSYTTAI RSNRLYSFSG SLPGYDSLVA VPGHAHLWQH STHIQASTAV
PHPHQPSFVA RQIRIIDAAN NTLSKELLGT SLSIYQALTV SNKLREICAT TQHRQCLIHS
PLAVWNYDQH AIEQDTDIVQ TVNQHLQDLS KPTGLSLHPY ATMGHVVLDD QGRFVSANSI
ILTFILKNTT HTQRIWDDMM QHTSQQFPAV YTHPLHAEPC LLQYKLKLPW SLTDVSSIQL
ATTLLFSMGL FITVRTQFSK STLLKSASGL GIAALFLAVA CYTTTMGIFH SFFRTTVHVV
PWFLHLLVCC TATLEHALCL TGAVVSKEKG IGIKERLGKG LQQVGVTMTT SLLGELFVLA
TGSTLNAPNV KAFCLFTSVA LVVAYVLNLT LFVAVLSIDI KRAELADLGD EEFEKRDSHH
ATVPARFHGN SGKSKTRRAL NAFFLCIVIL LLNFLSPNGH HQAPEISLSS LSTAASMNQW
SRISTQFWQA LNPTYAAETL QVHAPYVMIV SPTTADESQK QHLMHQLTTY YSDNFKALRQ
LMTQRSQQHS VLDAFHPYLL LAYSANIPSI ILLFVLVGII MWMTPWIREQ FMLPFLRKAF
VRIVTLILRM LSSMTPIKTD VWIRKVENEY NEDGMHMGAI SMQSRFNMLQ NKNKVRNVAI
KTLTGMHVAD IRDMHASGHL IASIGQQDGK IVLWDRNKDE WVARLDKLKR LGGGLNGWVA
AERNIRHYRH LKKKQQQQQQ QDMKYLPHAR CIQIDQDQQY IVAGFEHGLI CVWNADTVHL
IRELTIQQHQ LDDRVIRVLF IQDTVLSQQK KSIVSVHRNG KLREWDINTG DMTQCIESGH
TREITQTLII PNNQHMDTNT YYIITASKDG TTQCWSRTPR QWTRLHTLTY HNMITSVAAQ
QLHNGMGILV TGSNDGAVQV WNLDTGTAIC TLSKGGTVNK KMNTAATAEV GGPLLQFSTV
ARSTALDDGT HTAAYASQQQ QQQQHLVKSD HSDAVSQVVV TRISNPEFEH DTCPGCHTVI
NSGFFVASCA LDESVHAWRL NRTALSKQEV GCSQCAKDYH RRQQPLYSAR TTRPPSAGPV
SALRSKQRKL HASSSGVAGR MYTSGEESES MPQQQQQHEM TLSALFLGKL SQEAGRGLVF
CNNMVLAGCR RRRLTEDGDD WEVWFSSLQY YEPPSVEEDA ALIPVITYNL EKDDHAGDVS
SDLQGKEATG LGLKDQLLLN VFGIKKVRTN SNTASRPNVA VSRKSVKSEL ASAVKAVHFE
DIDDDTSATS TITAEEEDAE QDDDDEEEAY NALPFATIRC IVPIQGHGLG CDYGNFIKVV
TFGEEEAEEE EDVG
//
