ID A0A168Q6H6_MUCCL Unreviewed; 631 AA.
AC A0A168Q6H6;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Diacylglycerol kinase eta {ECO:0000256|ARBA:ARBA00017201};
DE EC=2.7.1.107 {ECO:0000256|ARBA:ARBA00012133};
GN ORFNames=MUCCIDRAFT_76354 {ECO:0000313|EMBL:OAD08768.1};
OS Mucor lusitanicus CBS 277.49.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=747725 {ECO:0000313|EMBL:OAD08768.1, ECO:0000313|Proteomes:UP000077051};
RN [1] {ECO:0000313|EMBL:OAD08768.1, ECO:0000313|Proteomes:UP000077051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 277.49 {ECO:0000313|EMBL:OAD08768.1,
RC ECO:0000313|Proteomes:UP000077051};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA Mccluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De Vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylates diacylglycerol (DAG) to generate phosphatidic
CC acid (PA). {ECO:0000256|ARBA:ARBA00002064}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase family.
CC {ECO:0000256|ARBA:ARBA00009280}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAD08768.1}.
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DR EMBL; AMYB01000001; OAD08768.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168Q6H6; -.
DR STRING; 747725.A0A168Q6H6; -.
DR VEuPathDB; FungiDB:QYA_76354; -.
DR OrthoDB; 4642163at2759; -.
DR Proteomes; UP000077051; Unassembled WGS sequence.
DR GO; GO:0004143; F:ATP-dependent diacylglycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR037607; DGK.
DR InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR11255; DIACYLGLYCEROL KINASE; 1.
DR PANTHER; PTHR11255:SF34; DIACYLGLYCEROL KINASE ETA; 1.
DR Pfam; PF00609; DAGK_acc; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000077051};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 144..331
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 15..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 71994 MW; 9773EEE91CEA46BE CRC64;
MPGVFMSNLL PSSLFSKKDA TVKPDPASSD GFVNDKGENV PQSNHKDKEK DIVPLQQTSI
SNAECSSSSS SSSSGNADIS TSHLTIDTKL PPKLRDEIPP PSSPIINHPN LLEEKKKFTR
PSMLNETSRL NTSVRFQDSK TEGRPSIYLF IFVNPLSGDC KGKDLVELPI QHFRLRRFPQ
VQVEIHNILD EQDRNLGVES IQLVEQMAKS GQLPSLEDEA LLDPHDSEVG KISKTVRTRH
IHVWSAGGDG TVMSAFELLV HHDIDLDYMF FSCIPFGTGN DFSQVLGWGR TIKHPNILGK
RLQNLEELIT ERLEKSEAAR LDIWQVEMTA YHGGYVRLAG PQRKDGHDVL EIDEREQQGT
YPHMVRKMCN YMSIGVQGYV GSGFEKHRAY NRFMNMLIYT SESAKWVFWR RFPSVTSFID
RIKFREETVL VVPDPDKKGT DQLPEGVPTM TTQPIDFVIQ NIPHIWGREV DLWGDAKYGL
EAVEGRSGHT DAETWTPQLA NDGKMEIFTI ENMVSYIKKL ANIRQHVSRV GQFETPFEIV
FREPPASSAT KQHGKKWWQS MTENKYKQRN VICIMCDGEF YILKDPKSLK FKRFAQVWTL
GRLDEHVRGR LVQDEQISQK RQREQQHLGT L
//
