ID A0A170UFF1_9ACTN Unreviewed; 650 AA.
AC A0A170UFF1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=biotin carboxylase {ECO:0000256|ARBA:ARBA00013263};
DE EC=6.3.4.14 {ECO:0000256|ARBA:ARBA00013263};
GN ORFNames=STXM2123_264 {ECO:0000313|EMBL:GAT79563.1};
OS Streptomyces sp. F-3.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1840095 {ECO:0000313|EMBL:GAT79563.1, ECO:0000313|Proteomes:UP000078145};
RN [1] {ECO:0000313|EMBL:GAT79563.1, ECO:0000313|Proteomes:UP000078145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wang L.S., Gao P.J., Liu L., Zhang H.Q., Cheng Z., Sun X.M.;
RT "Streptomyces sp. F-3 geneom sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAT79563.1}.
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DR EMBL; BDDR01000001; GAT79563.1; -; Genomic_DNA.
DR RefSeq; WP_067388382.1; NZ_BDDR01000001.1.
DR AlphaFoldDB; A0A170UFF1; -.
DR STRING; 1840095.STXM2123_264; -.
DR OrthoDB; 9760256at2; -.
DR Proteomes; UP000078145; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000078145}.
FT DOMAIN 1..448
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 120..319
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 556..638
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 650 AA; 69134 MW; F6E678427AF6E52C CRC64;
MFETVLVANR GEIAVRVIRT LRALGVRSVA VFSDADADAR HVREADTAVR IGPAPAAESY
LCADRLLEAA ARTGAQAVHP GYGFLAENAG FARACEEAGL VFIGPPADAI SLMGDKIRAK
ETVAAAEVPV VPGSSGFGLT DDRLAEAARR IGLPVLLKPS AGGGGKGMRL VRDADRLAEE
IAAARREARA SFGDDTLLVE RWIDRPRHIE IQVLADGHGN VVHLGERECS LQRRHQKIVE
EAPSVLLDEE TRAAMGEAAV RAARSCGYRG AGTVEFIVPG GDPTTYYFME MNTRLQVEHP
VTEMITGIDL VEWQLRVAAG EPLPFTQKDV RLTGHAIEAR LCAEDPARGF LPSGGTVLRL
REPHGEGVRT DSGLSEGTEV GSLYDPMLSK VIAHGPDRET ALRRLRAALA RTVVLGVQTN
TGFLRRLLAH PAVVAGELDT GLVERVAGEL AVTEVPEEVY EAAAAVRLEA LRPKGGGWID
PFSVPNGWRL GGEPKPVAFP LRVPGHDPVT HPVRGTHAVT DDTVAVTLDG VRHTFHRAGD
WLGRDGDAWH VRDHDPVAAS LTRAAHFGAD SLTAPMPGTV TVVKVAVGDK VTAGQSLLVV
EAMKMEHVIS APHAGTVTEL DVTPGTTVAM DQVLAVIAPD DEDGAKEETA
//
