ID A0A170ZW87_9ACTN Unreviewed; 508 AA.
AC A0A170ZW87;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=STXM2123_4143 {ECO:0000313|EMBL:GAT83442.1};
OS Streptomyces sp. F-3.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1840095 {ECO:0000313|EMBL:GAT83442.1, ECO:0000313|Proteomes:UP000078145};
RN [1] {ECO:0000313|EMBL:GAT83442.1, ECO:0000313|Proteomes:UP000078145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wang L.S., Gao P.J., Liu L., Zhang H.Q., Cheng Z., Sun X.M.;
RT "Streptomyces sp. F-3 geneom sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAT83442.1}.
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DR EMBL; BDDR01000027; GAT83442.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A170ZW87; -.
DR STRING; 1840095.STXM2123_4143; -.
DR OrthoDB; 1931120at2; -.
DR Proteomes; UP000078145; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR43065:SF48; TWO-COMPONENT SENSOR HISTIDINE KINASE-RELATED; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:GAT83442.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000078145};
KW Transferase {ECO:0000313|EMBL:GAT83442.1}.
FT DOMAIN 18..124
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 296..475
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 480..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 508 AA; 55442 MW; 83C94AADF16C5AE8 CRC64;
MNGRPLPCSP EEIGSLFLFE KLSDAQLERL CREGRVERFD PGPVYAEGEP ATCFYVLLQG
TVVLSRRVGG DDVEVVRSSQ PGAYAGAMQA YLGDRMPQVY NNSMRVTEPT RFFVLSAGTF
SDVVHEWFPM AVHLLEGLFF GSRNAQATVG QRERLLALGS LSAGLTHELN NPAAAAVRAT
ATLRERVAKM RRKLALIAEG PFSRDQLASL VDIQQRTAER VAKAPVLTPL EASDREDALA
DWLEDHGVGQ GWQLAPTFVQ AGLDVDWLEQ VAAVVGEEIL PGAVGWLTYT VETELLMDEI
ADSTTRVSRL VDAAKQYSQL DRAPYQVADV HELLDSTLLM LSGKTGPRIR VVKEYDRTLP
RIPAYPAELN QVWTNLIDNA VGAMEEADGD GTLTVRTALD GDRLLVEFRD TGPGVPPEIR
DRIFEPFFTT KPVGRGTGLG LDISRRIVVN KHHGSLEVES VPGDTRFRVL LPLTAAGPDD
TAHTALAPAA PGGPPLASEN RTTSRERT
//
