ID A0A171A8B8_9ACTN Unreviewed; 2001 AA.
AC A0A171A8B8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=STXM2123_4325 {ECO:0000313|EMBL:GAT83624.1};
OS Streptomyces sp. F-3.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1840095 {ECO:0000313|EMBL:GAT83624.1, ECO:0000313|Proteomes:UP000078145};
RN [1] {ECO:0000313|EMBL:GAT83624.1, ECO:0000313|Proteomes:UP000078145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wang L.S., Gao P.J., Liu L., Zhang H.Q., Cheng Z., Sun X.M.;
RT "Streptomyces sp. F-3 geneom sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAT83624.1}.
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DR EMBL; BDDR01000029; GAT83624.1; -; Genomic_DNA.
DR STRING; 1840095.STXM2123_4325; -.
DR Proteomes; UP000078145; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:GAT83624.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000078145}.
FT DOMAIN 378..693
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT DOMAIN 1218..1400
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1452..1610
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1686..1713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2001 AA; 217216 MW; A00ABE6DDFCFB720 CRC64;
MALALGEGCM AVQRTISAAA RRIVDLVRAH KAGITEQDLL LEATRAFGLP RQRLVRLLTE
AIDGGLLIAS GDGLLRAVPH HAEDCGQPPA SGTATARGAS EARASGLRAV ALDIESVVRT
TATAPYVERT VYEVAAVRFG VDRTWVTAAP HWQRYLTLSA DAADHIRDDT VRDAVLTQGV
PAKQAWTELR AFLADADVVV AYNGTGLDFT VVSEEATRAG TEDPLAGMST VDALYIAHAL
WPTVPSHRLQ DLARHLELPT AGVRAHTADG DAALLVRLLH RAAAEYAAWR PELRELITDA
CWDSAAWRLL RELAEGQPTE HRESLVWSQA EVARLLGAEL SRHTPRRAFD GRSPGRAAVV
VPDELRGSDG RVEPTALARV VHGSRVEPRP AQQRMTETLH EWTDRGVSGL LEAPTGTGKS
YAVLAAALEW LAGAEHRTAV IATYTKQLQS QMARDLHDLE RALPGVLTVA DLVKGQSNRL
SLAALTKALA DATRLAPARG GARTRPAQKS RRHELAVYLA LRLLAAEEPP HSWTARSVDP
VDLPAFFSTY VGDGLSSWLE SLSQRDGDYG PGASTPLAVH TDTVREAISG HRLILANHAL
ILSHLDDLRA LGPDVLLVLD EAHELENAAT SALTVEVDYQ DLEDVLAEHQ AWIAEALPGA
ERERAAGAID ELDRLLDDER LPRLAARAFD ARAKGAGVRV GSRATTVASP YAGTSGTRDT
RRLSHLLDRV AKALSACRIA LERYVAQHSG HIDALAAERL TALAAHTDDL ATALERITAD
INDLLNPAAT LDSADSAVPS RVVHLEELAE PKAELRSYRF RVASSPVDLP ADPEWRRCLE
SFDRVHYVSA TLRVAGEWDF IRSRLGLPDT LPTLALNSPF DLRNQAEVVC FSDFPSWAEQ
EEGAMRTVAH QVAGYAAEMT RRRSDGRGFD GGGLILTTAR STAAGIGCHL TAELRSRGLE
TPVVEALTLG NSRAYQTFTD PRDGGGFLVG TKGLWQGVDV SDAERLRLVW INKLPFAPFA
APIVEARRAA VADRAAQAGH PDPEGAATEH YYLPLAALQL RQAVGRLIRS DRHRGVVVIS
DRKLAGQNSL RRSYRRAFLG SLDEGLQRPD PDTGERGGGN VVTMTEGWRR IWRFLADHGA
LDPDRAAELC TDAALERHTL LPHTRLIRKL ALTPEETGKL REQGMLAAVV RERCARIGGL
LKFSEEPVPL KPAQEAVITA VAEGRNVLGL LPTGFGKSFT FQLPALVLPG VTVVVSPLVA
LMHDQALELN RAIGGAVRAL ISPLRESSSR AGKTEVADQL LGRADHDIRL VYVSPERLCQ
RRFREIVRKA AQAGRVTRIA VDEAHTLAQW EDFRPSMRRV GRFLDELRRD HGVAVTAVTA
TANRAVHEAL REGLFGLPAA IPAPDSAEAR AEAERPGVVD ALVTVRENPI RPELAIFRRS
LDRLGQGGVA GLVERVVDAL DGHAILYCLT VKEVNTLHTH LREYVGNSGV RVLRFHGRLT
EAEKTAVMTE FREAPRQDDD SFAPVVVVAT SAFGLGVNRP DVRTVMCVSP PTDLAALYQQ
IGRAGRDSAG RGTAADGPVN CGLALATSRG LRMAGFMTGQ ELKPSLLRRM GHLVLARRGG
TLDPVQLADT LMAEDVAAGE LDQSDLEDRY TQERYRSGIM RAFSALADLG AVEDQGDYPP
CCAVKPGELR PVPHGTPRTD GPVGEEGEGE EETELARIEQ TVIDTALSWD TPRQVDVRLL
HRQLTAHCAG YSEYADSPAA TWELLADLHD RGLLDVSAAP SRRLVTGLTV TGGREPTLPG
GYLPLLGRRG RRAAEELARL RHFFDANTVC AQRLLADYFG VTDLPEGCCS TARCRCSACW
DTGHGPVDER RPAVAEAFHS PRPRDGGGTD TSLRDQRVDL QVHRLLQLQP QGMHPRRLWH
ALRGDESSYH PGKRKMVALP PALRDSRHFG GRADLPYAAV GQSLARLAAR GVAVEDERGL
WRAIRPARHA VNRSERKGSG A
//
