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Database: UniProt
Entry: A0A171AN58_9ACTN
LinkDB: A0A171AN58_9ACTN
Original site: A0A171AN58_9ACTN 
ID   A0A171AN58_9ACTN        Unreviewed;       647 AA.
AC   A0A171AN58;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=STXM2123_4649 {ECO:0000313|EMBL:GAT83948.1};
OS   Streptomyces sp. F-3.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1840095 {ECO:0000313|EMBL:GAT83948.1, ECO:0000313|Proteomes:UP000078145};
RN   [1] {ECO:0000313|EMBL:GAT83948.1, ECO:0000313|Proteomes:UP000078145}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wang L.S., Gao P.J., Liu L., Zhang H.Q., Cheng Z., Sun X.M.;
RT   "Streptomyces sp. F-3 geneom sequencing.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAT83948.1}.
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DR   EMBL; BDDR01000035; GAT83948.1; -; Genomic_DNA.
DR   EnsemblBacteria; GAT83948; GAT83948; STXM2123_4649.
DR   Proteomes; UP000078145; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000078145};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078145}.
FT   DOMAIN      339    467       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      553    622       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     347    354       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   647 AA;  71231 MW;  EBD8F4B77B197D3B CRC64;
     MADVPADLAA VWPRVLEQLL GDGRGQGVEA KDEHWIRRCQ PLALVADTAL LAVPNEFAKG
     VLEGRLAPVV SETLSRECGR PIRIAITVDS SVGESPVPAP PAPRYEEPRY EEQELPTGQG
     GYEGYGRHRS DGHRSGHADQ LPGTGSDQLP PPRTGPQPVD DSDPLPTARP AYPGEYADYQ
     RPEPGAWPRR PQDDYGWQQQ RLGFPERDPY ASPSAQDPYG PQDPYAPSAP SQDYRPQPVD
     RPSYDPSRPD YEQRDTGRRD LPEPPVGSGQ AHRGGPMGPS RPASGASGPL TAQPAPASGP
     GEPTARLNPK YLFDTFVIGA SNRFAHAAAV AVAEAPAKAY NPLFIYGESG LGKTHLLHAI
     GHYARSLYPG TRVRYVSSEE FTNEFINSIR DGKGDSFRKR YREMDILLVD DIQFLADKES
     TQEEFFHTFN TLHNANKQIV LSSDRPPKQL VTLEDRLRNR FEWGLITDVQ PPELETRIAI
     LRKKAVQEQL NAPPEVLEFI ASRISRNIRE LEGALIRVTA FASLNRQPVD LGLTEIVLKD
     LIPGGEDSAP EITAAAIMAA TADYFGLTVE DLCGTSRGRA LVTARQIAMY LCRELTDLSL
     PKIGAQFGGR DHTTVMHADR KIRALMAERR SIYNQVTELT NRIKNGS
//
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