ID A0A172Q5K5_9STRE Unreviewed; 389 AA.
AC A0A172Q5K5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN ORFNames=A0O21_01235 {ECO:0000313|EMBL:AND78749.1};
OS Streptococcus pantholopis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1811193 {ECO:0000313|EMBL:AND78749.1, ECO:0000313|Proteomes:UP000077317};
RN [1] {ECO:0000313|EMBL:AND78749.1, ECO:0000313|Proteomes:UP000077317}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TA 26 {ECO:0000313|EMBL:AND78749.1,
RC ECO:0000313|Proteomes:UP000077317};
RX PubMed=27226124; DOI=10.1099/ijsem.0.001189;
RA Bai X., Xiong Y., Lu S., Jin D., Lai X., Yang J., Niu L., Hu S., Meng X.,
RA Pu J., Ye C., Xu J.;
RT "Streptococcuspantholopis sp. nov., isolated from faeces of the Tibetan
RT antelope (Pantholops hodgsonii).";
RL Int. J. Syst. Evol. Microbiol. 66:3281-3286(2016).
RN [2] {ECO:0000313|Proteomes:UP000077317}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TA 26 {ECO:0000313|Proteomes:UP000077317};
RA Bai X.;
RT "Streptococcus antelopensis sp. nov., isolated from the feces of the
RT Tibetan antelope (Pantholops hodgsonii) in Hoh Xil National Nature Reserve,
RT Qinghai, China.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in both transcription termination and
CC antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
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DR EMBL; CP014699; AND78749.1; -; Genomic_DNA.
DR RefSeq; WP_067060262.1; NZ_CP014699.1.
DR AlphaFoldDB; A0A172Q5K5; -.
DR STRING; 1811193.A0O21_01235; -.
DR KEGG; spat:A0O21_01235; -.
DR Proteomes; UP000077317; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR CDD; cd22529; KH-II_NusA_rpt2; 1.
DR CDD; cd04455; S1_NusA; 1.
DR Gene3D; 3.30.300.20; -; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.30.1480.10; NusA, N-terminal domain; 1.
DR HAMAP; MF_00945_B; NusA_B; 1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR025249; KH_dom_NusA-like.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR030842; NusA_bac.
DR InterPro; IPR036555; NusA_N_sf.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR013735; TF_NusA_N.
DR InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR NCBIfam; TIGR01953; NusA; 1.
DR PANTHER; PTHR22648; TRANSCRIPTION TERMINATION FACTOR NUSA; 1.
DR PANTHER; PTHR22648:SF0; TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA; 1.
DR Pfam; PF13184; KH_5; 2.
DR Pfam; PF08529; NusA_N; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 2.
DR SUPFAM; SSF69705; Transcription factor NusA, N-terminal domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00945};
KW Reference proteome {ECO:0000313|Proteomes:UP000077317};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription antitermination {ECO:0000256|ARBA:ARBA00022814,
KW ECO:0000256|HAMAP-Rule:MF_00945};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription termination {ECO:0000256|ARBA:ARBA00022472,
KW ECO:0000256|HAMAP-Rule:MF_00945}.
FT DOMAIN 229..306
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 315..374
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 367..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 389 AA; 44170 MW; 030F149880310ED8 CRC64;
MSKEMLEAFR ILEEEKHIDK KDIIEAVEES LKSAYKRRYG QAESCVVEFD EKTGDFQVYT
VREVVEEVFD SRLEISLEDA LAISSAYEIG DKIRFAESVA EFGRVAAQSA KQTIMEKMRR
QMREVTFNEY KEREGEIMTG TVERFDQRFI YVNLGTLEAQ LSHQDQIPGE TFKSHDRIEV
YVYKVENNPK GVNVFVSRSH PQFIKRIMEQ EIPEVFDGTV EIMSVSREAG DRTKIAVRSH
NPNVDAIGTI VGRGGSNIKK VTSKFHPKRI DPKTGAALPM EENIDVIQWV DDPAEFIYNA
IAPAEVDMVL FDDEDPKRAT VVVPDSKLSL AIGRRGQNVR LAAHLTGYRI DIKSASEYDE
MEAQREEFLA AEAKNAESEP SEPVLDGTE
//
