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Database: UniProt
Entry: A0A172RVS9_9ACTN
LinkDB: A0A172RVS9_9ACTN
Original site: A0A172RVS9_9ACTN 
ID   A0A172RVS9_9ACTN        Unreviewed;       492 AA.
AC   A0A172RVS9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-SEP-2017, entry version 12.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AAY81_00005 {ECO:0000313|EMBL:ANE21826.1}, SAMN02910314_00195
GN   {ECO:0000313|EMBL:SEO41957.1};
OS   Denitrobacterium detoxificans.
OC   Bacteria; Actinobacteria; Coriobacteriia; Eggerthellales;
OC   Eggerthellaceae; Denitrobacterium.
OX   NCBI_TaxID=79604 {ECO:0000313|EMBL:ANE21826.1, ECO:0000313|Proteomes:UP000077372};
RN   [1] {ECO:0000313|EMBL:ANE21826.1, ECO:0000313|Proteomes:UP000077372}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NPOH1 {ECO:0000313|EMBL:ANE21826.1,
RC   ECO:0000313|Proteomes:UP000077372};
RA   Anderson R.A.;
RT   "Genome of Denitrobactrium detoxificans, a ruminal bacterium that
RT   respires on nitrocompounds.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:SEO41957.1, ECO:0000313|Proteomes:UP000182975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21843 {ECO:0000313|EMBL:SEO41957.1,
RC   ECO:0000313|Proteomes:UP000182975};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP011402; ANE21826.1; -; Genomic_DNA.
DR   EMBL; FOEC01000001; SEO41957.1; -; Genomic_DNA.
DR   RefSeq; WP_066659806.1; NZ_FOEC01000001.1.
DR   EnsemblBacteria; ANE21826; ANE21826; AAY81_00005.
DR   KEGG; ddt:AAY81_00005; -.
DR   PATRIC; fig|79604.3.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000077372; Chromosome.
DR   Proteomes; UP000182975; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077372,
KW   ECO:0000313|Proteomes:UP000182975};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077372}.
FT   DOMAIN      179    310       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      400    468       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     187    194       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   492 AA;  54991 MW;  1C3DBA710B81C55F CRC64;
     MQGENIDAVW QSITAHIKTY DNMDSSQIDA FFTRLQPQAF SEGYLMLTAD TDFIRKWIES
     HYMQVIKQAL EEIYRVPFTI QIEVDPTSKS PIVPAAAPAV PAPAPAAQPV QPAPAPVAAA
     PVAQPSAPMQ AESAPAQPTA SDGMFSVSSY LFDNFVRGTS NRMAYSMAIA VAETPGSNQL
     NPLFIYGKSG LGKTHLLRSI QNYVQGNYPH MRSVYVDTME LVNDYTDAAI SNNPKAFTEF
     KQRYENADVL LIDDVQGLQG RKETLNMVFQ IMNRMIDSGK QVVLSADRAP KNIDIDERYK
     SRFNMGGTCD IQPPELETKM GIIRKFIEEC KMAGGGNFDI PNDVQEYIAK NSSSNVRELK
     SAVTKVLFEL RNGGCEEITI EEASRLLSDH FSGGAMKKLT IGEVQACVER FYNVSHSDLV
     GKKRSANITH ARQIAIYLCR TMIDIPFKTI GEEFNRDHST IMYSYRCVDE KVKESRPVNE
     ELELLRQMIL DQ
//
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