ID A0A172TA85_9DEIO Unreviewed; 374 AA.
AC A0A172TA85;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Prephenate dehydrogenase {ECO:0000256|ARBA:ARBA00016891};
DE EC=1.3.1.12 {ECO:0000256|ARBA:ARBA00012068};
GN ORFNames=SU48_09255 {ECO:0000313|EMBL:ANE43930.1};
OS Deinococcus puniceus.
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=1182568 {ECO:0000313|EMBL:ANE43930.1, ECO:0000313|Proteomes:UP000077363};
RN [1] {ECO:0000313|EMBL:ANE43930.1, ECO:0000313|Proteomes:UP000077363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY1 {ECO:0000313|EMBL:ANE43930.1,
RC ECO:0000313|Proteomes:UP000077363};
RA Kim M.K., Srinivasan S., Lee J.-J.;
RT "Deinococcus puniceus/DY1/ whole genome sequencing.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADH; Xref=Rhea:RHEA:13869, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001162};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005067}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007964}.
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DR EMBL; CP011387; ANE43930.1; -; Genomic_DNA.
DR RefSeq; WP_064015002.1; NZ_CP011387.1.
DR AlphaFoldDB; A0A172TA85; -.
DR STRING; 1182568.SU48_09255; -.
DR KEGG; dpu:SU48_09255; -.
DR PATRIC; fig|1182568.3.peg.1925; -.
DR OrthoDB; 9802008at2; -.
DR UniPathway; UPA00122; UER00961.
DR Proteomes; UP000077363; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04909; ACT_PDH-BS; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR003099; Prephen_DH.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000077363};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Tyrosine biosynthesis {ECO:0000256|ARBA:ARBA00022498}.
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..310
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
FT DOMAIN 305..374
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT COILED 251..278
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 374 AA; 39674 MW; D6737F278242C1A0 CRC64;
MTTPATPSAD SAPLPPPLFD TAVVAGVGLI GGSVALGLRQ RFLARRVIGY DANPDVLREA
EALGVVDEVR AMPGEWLRGA DLVVLAAPMR ALTPLARDLA PYLNPAALVT DVGSVKAGIA
AEMEALGVRN FVPGHPMAGS ERGGVTHARA ALLENAVWVL TPTDHTPLTA LSRARMLVEH
LGAAPVVMPP EAHDALVATV SHLPYLASLA LTHMVARDER LSLLAAGGFR DLTRVASGDP
RMSRDMVVEN KVALREALAR FRRQLERLEA DLDEPEELLA AATEGKRTRD SLPVVRRSLL
PPKHDLVVAV PDKPNQIGAV TQALGAAGVN IKDIEVLAIR EDGGAMRLGL ETLEDVAHAS
QILREAGFEV RGRS
//