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Database: UniProt
Entry: A0A172U329_9GAMM
LinkDB: A0A172U329_9GAMM
Original site: A0A172U329_9GAMM 
ID   A0A172U329_9GAMM        Unreviewed;       438 AA.
AC   A0A172U329;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   05-JUL-2017, entry version 11.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ANE53720.1};
GN   ORFNames=AYM39_00005 {ECO:0000313|EMBL:ANE53720.1};
OS   Methylomonas sp. DH-1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylomonas.
OX   NCBI_TaxID=1727196 {ECO:0000313|EMBL:ANE53720.1, ECO:0000313|Proteomes:UP000077385};
RN   [1] {ECO:0000313|EMBL:ANE53720.1, ECO:0000313|Proteomes:UP000077385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DH-1 {ECO:0000313|EMBL:ANE53720.1,
RC   ECO:0000313|Proteomes:UP000077385};
RA   Hur D.H., Na J.-G., Jeong H., Yoon S.H., Lee E.Y.;
RT   "Complete genome sequence of the methanotrophic bacterium Methylomonas
RT   sp. DH-1.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP014360; ANE53720.1; -; Genomic_DNA.
DR   RefSeq; WP_064019975.1; NZ_CP014360.1.
DR   EnsemblBacteria; ANE53720; ANE53720; AYM39_00005.
DR   KEGG; mdh:AYM39_00005; -.
DR   KO; K02313; -.
DR   Proteomes; UP000077385; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077385};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077385}.
FT   DOMAIN      135    266       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      346    415       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     143    150       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   438 AA;  49663 MW;  536A10579B0BC296 CRC64;
     MSVIWNNCLA KLEHEIPSAD FSTWIRPLQA VESDSQLKLL APNRFIIDHI KQHFFSIIED
     AVNEFSNATL SVHFEIGSKK SPAIKAPTLS KSSTQKKNQP NFLNKAFTFE SFVEGKSNQL
     ARAASVTVSD NIGKVYNPLF IYGSSGLGKT HLMHAIGNAV LLKKPDANIV YLHSEKFVQD
     MVKALQQNSI NQFKEYYRSI DILLMDDIQF LAGKERSQEE FFHTFNNLLD NKHQVVLTCD
     KYPKEIDGLE DRLKSRFGWG LPVAIEPPDL ETRTAILIKK ALQVGVELDQ EIAFFIAKRI
     PSNVRDLEGA LRRVVANSQF TGREITLEFT KEALHDLISL QDKLISIDNI QKTVAEYFKI
     RVADLSSKNR KQSITRPRQV AMSLARELTS HSYPEIGDAF GGRDHTTVIN ACKRIAELKE
     EDVKMAEDYK NLLRTLSH
//
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