ID   A0A172UHG8_9MYCO        Unreviewed;       393 AA.
AC   A0A172UHG8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Glutathione-dependent formaldehyde dehydrogenase {ECO:0000313|EMBL:ANE78589.1};
GN   ORFNames=A7U43_03855 {ECO:0000313|EMBL:ANE78589.1};
OS   Mycobacterium adipatum.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1682113 {ECO:0000313|EMBL:ANE78589.1, ECO:0000313|Proteomes:UP000077143};
RN   [1] {ECO:0000313|EMBL:ANE78589.1, ECO:0000313|Proteomes:UP000077143}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YC-RL4 {ECO:0000313|EMBL:ANE78589.1,
RC   ECO:0000313|Proteomes:UP000077143};
RA   Ren L., Fan S., Ruth N., Jia Y., Wang J., Qiao C.;
RT   "Complete genome sequence of a phthalic acid esters degrading Mycobacterium
RT   sp. YC-RL4.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CP015596; ANE78589.1; -; Genomic_DNA.
DR   RefSeq; WP_067991355.1; NZ_CP015596.1.
DR   AlphaFoldDB; A0A172UHG8; -.
DR   STRING; 1682113.A7U43_03855; -.
DR   KEGG; madi:A7U43_03855; -.
DR   OrthoDB; 241504at2; -.
DR   Proteomes; UP000077143; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08283; FDH_like_1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077143};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          26..144
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          189..258
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   393 AA;  42287 MW;  7CD539CC06E9A90C CRC64;
     MKAVTWHGKR DVRVEQVPDP RVEEPTDAII EVTSTNICGS DLHLYEVLGA FMNPGDILGH
     EPMGIVREIG SGVTDLAVGD RVVIPFQISC GSCFMCDHEL YTQCETTQVR DQGMGAALFG
     YSELYGQVPG GQAELLRVPQ AQFTHIKVPD GPPDSRFVYL SDVLPTAWQA VAYADIPAGG
     SVTVLGLGPI GDMAARIAAH LGYDVIAVDR VPARLDRAQA RGIRTIDLAA QENPIGDVIR
     ELTGGRGTDS VIDAVGMEAH GSPITKAAQQ LTGLLPDFLA KPFMEKAGVD RLDALYSAID
     IVRRGGTISL IGVYGGMADP LPMLTLFDKQ VQLRMGQANV KKWVPDIMPL LTDEDPLGVD
     DFATHTLPLD EAPHAYDIFQ RKADGAVKVI LKP
//