ID A0A172UUS0_9MYCO Unreviewed; 524 AA.
AC A0A172UUS0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Adenylyl cyclase {ECO:0000313|EMBL:ANE82680.1};
GN ORFNames=A7U43_06090 {ECO:0000313|EMBL:ANE82680.1};
OS Mycobacterium adipatum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1682113 {ECO:0000313|EMBL:ANE82680.1, ECO:0000313|Proteomes:UP000077143};
RN [1] {ECO:0000313|EMBL:ANE82680.1, ECO:0000313|Proteomes:UP000077143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YC-RL4 {ECO:0000313|EMBL:ANE82680.1,
RC ECO:0000313|Proteomes:UP000077143};
RA Ren L., Fan S., Ruth N., Jia Y., Wang J., Qiao C.;
RT "Complete genome sequence of a phthalic acid esters degrading Mycobacterium
RT sp. YC-RL4.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; CP015596; ANE82680.1; -; Genomic_DNA.
DR RefSeq; WP_068002000.1; NZ_CP015596.1.
DR AlphaFoldDB; A0A172UUS0; -.
DR STRING; 1682113.A7U43_06090; -.
DR KEGG; madi:A7U43_06090; -.
DR OrthoDB; 368920at2; -.
DR Proteomes; UP000077143; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000077143};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 258..310
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 342..466
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 524 AA; 56448 MW; F0531F2F539B968D CRC64;
MSAEVTPIGR VSAFVRWVAR TPWPVFGLGM VQADIIGALL VLGFLRYGLP PEDRIQLQEL
PAFNLAVFLA YLFVSFTIAA YITLRMLIPV IRWQRRDTLL GDTSTTITEV ARVRALKMPF
YRSVINVTNW CLGSIVFIVA SWPVASKSAP VVAVATALGA TAVAIIGYLQ SERVLRPVAV
AALRTGVPEN FRAPGVILRQ VLTWVLSTGV PILAIVLAVV ASKFEILNAP ADKLTTPILL
LAIAALLIGL VGTVLVSMSI ADPLRQLRWA LGEVQRGNYN AHMQIYDASE LGLLQAGFND
MVRDLAERQR LRDLFGRYVG EDVARRALER GTELGGQERD VAVLFVDLVG STQLASTIPA
SEVVNLLNEF FRVIVDTVNK HGGFVNKFQG DAALAIFGAP IEHPDASGAA LAASRELHDE
LVNVLGQTEF GIGVSAGRAI AGHIGAQARF EYTVIGDPVN EAARLTELAK LEEGHVLASA
IAVSGALDAE ALCWDVGEIV ELRGRKAPTQ LARPVRPYTR ALSG
//
