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Database: UniProt
Entry: A0A172X687_9MICO
LinkDB: A0A172X687_9MICO
Original site: A0A172X687_9MICO 
ID   A0A172X687_9MICO        Unreviewed;       477 AA.
AC   A0A172X687;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-NOV-2017, entry version 14.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=A0130_11265 {ECO:0000313|EMBL:ANF32181.1};
OS   Leifsonia xyli.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae; Leifsonia.
OX   NCBI_TaxID=1575 {ECO:0000313|EMBL:ANF32181.1, ECO:0000313|Proteomes:UP000077845};
RN   [1] {ECO:0000313|EMBL:ANF32181.1, ECO:0000313|Proteomes:UP000077845}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SE134 {ECO:0000313|EMBL:ANF32181.1,
RC   ECO:0000313|Proteomes:UP000077845};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP014761; ANF32181.1; -; Genomic_DNA.
DR   RefSeq; WP_064110461.1; NZ_CP014761.1.
DR   EnsemblBacteria; ANF32181; ANF32181; A0130_11265.
DR   GeneID; 33967988; -.
DR   Proteomes; UP000077845; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077845};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077845}.
FT   DOMAIN      167    295       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      379    448       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     175    182       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   477 AA;  53269 MW;  6D445ABC0F8C495A CRC64;
     MAGSEEPIAA AWQDVLGKLE TDDRITPQLY GFLSLVEPKG IMAGTFYLEV PNEFTRGMIE
     QRSRLPLLNA ISGLDDALAV NTFAIVVNPE IQQESMTAAA EPETAAAYVE QVAPPLVSQP
     APEITAPPRG GDTRLNSKYS FDNFVIGQSN RFAHAAAVAV AEAPAKAYNP LFIYGDSGLG
     KTHLLHAIGH YAMSLYPGIR VRYVSSEEFT NDFINSIANN RGSSFQARYR NIDILLIDDI
     QFLQRAVETQ EAFFHTFNTL HDHNKQVVIT SDLPPKMLTG FEDRMRSRFE WGLITDVQVP
     DLETRIAILR KKAQSEKIQV PDDILEFMAT KVSSNIRELE GTLIRVTAFA SLNRTPVDMP
     LVQTVLKDLI TLDDDNVIAP TDIITNTAEY FKLSVDDLYG SSRSQAVATA RQIAMYLCRE
     LTNLSLPKIG QLFGGRDHTT VMYANKKISE LMKERRSIYN QVTELTSRIK QNHRYGK
//
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