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Database: UniProt
Entry: A0A176KT56_9ACTN
LinkDB: A0A176KT56_9ACTN
Original site: A0A176KT56_9ACTN 
ID   A0A176KT56_9ACTN        Unreviewed;       661 AA.
AC   A0A176KT56;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   30-AUG-2017, entry version 12.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:OAA95455.1};
GN   ORFNames=A6P39_38990 {ECO:0000313|EMBL:OAA95455.1};
OS   Streptomyces sp. FXJ1.172.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=710705 {ECO:0000313|EMBL:OAA95455.1, ECO:0000313|Proteomes:UP000077074};
RN   [1] {ECO:0000313|EMBL:OAA95455.1, ECO:0000313|Proteomes:UP000077074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAA95455.1,
RC   ECO:0000313|Proteomes:UP000077074};
RA   Liu M., Liu N., Shang F., Huang Y.;
RT   "Activation and identification of NC-1, a novel cryptic
RT   cyclodepsipeptide from red soil-derived Streptomyces sp. FXJ1.172.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAA95455.1}.
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DR   EMBL; LWRP01000202; OAA95455.1; -; Genomic_DNA.
DR   EnsemblBacteria; OAA95455; OAA95455; A6P39_38990.
DR   Proteomes; UP000077074; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077074};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897}.
FT   DOMAIN      354    482       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      568    637       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     362    369       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   661 AA;  73193 MW;  B445E87CFA2A1AD7 CRC64;
     MWPRVLEQLL GEGRGQGVEA KDEHWIRRCQ PLALVADTAL LAVPNEFAKG VLEGRLAPIV
     SETLSRECGR PIRIAITVDD SAGEPPAPAP VQQPPKPRYE EPELPSGPYE GYGRHRAAEQ
     PPADGPQPRA DQLPVVRPAY PSEFQRREPG TWPRPAQDEY SWQQPRLGFP ERDPYASPSS
     QDAYGSGPDS YGAPSPDYRP QGMDRPSYEQ QRGERGDYDG PRGDYEPSRP DYDSPRSDYD
     SGRSEYGSGR SEYGSGRSDY DSSRAEYDQR DPVRRELPEQ PAGGPAHRGG PGRPDLPATG
     APGPLAAQPA PASGAGEPTA RLNPKYLFDT FVIGASNRFA HAAAVAVAEA PAKAYNPLFI
     YGESGLGKTH LLHAIGHYAR SLYPGTRVRY VSSEEFTNEF INSIRDGKGD SFRKRYREMD
     ILLVDDIQFL ADKESTQEEF FHTFNTLHNA NKQIVLSSDR PPKQLVTLED RLRNRFEWGL
     ITDVQPPELE TRIAILRKKA VQEQLNAPPE VLEFIASRIS RNIRELEGAL IRVTAFASLN
     RQPVDLGLTE IVLKDLIPGG EDSAPEITAT AIMGATADYF GLTVEDLCGT SRGRALVTAR
     QIAMYLCREL TDLSLPKIGA QFGGRDHTTV MHADRKIRAL MAERRSIYNQ VTELTNRIKN
     G
//
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