ID A0A176KXI2_9ACTN Unreviewed; 483 AA.
AC A0A176KXI2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=MFS transporter {ECO:0000313|EMBL:OAA96810.1};
GN ORFNames=A6P39_32055 {ECO:0000313|EMBL:OAA96810.1};
OS Streptomyces sp. FXJ1.172.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=710705 {ECO:0000313|EMBL:OAA96810.1};
RN [1] {ECO:0000313|EMBL:OAA96810.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAA96810.1};
RA Liu M., Liu N., Shang F., Huang Y.;
RT "Activation and identification of NC-1, a novel cryptic cyclodepsipeptide
RT from red soil-derived Streptomyces sp. FXJ1.172.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAA96810.1}.
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DR EMBL; LWRP01000167; OAA96810.1; -; Genomic_DNA.
DR RefSeq; WP_067053528.1; NZ_CP119133.1.
DR AlphaFoldDB; A0A176KXI2; -.
DR STRING; 710705.A6P39_32055; -.
DR OrthoDB; 9808458at2; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR InterPro; IPR045018; Azg-like.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 50207 MW; 5525A99550455910 CRC64;
MSTSAPAKAP TPEKPGRAPV HGALDRYFKI SERGSSVARE IRGGFATFFA MAYIIVLNPI
ILGSAKDMYG HHLNNGQLVT ATALTAAFST LLMGVIGNVP IALAAGLGVN SVVALQLAPR
MSWPDAMGMV VLAGFVVMLL VATGLRERVM NAVPFGLRKA ISIGIGLFIM LIGLVDSGFV
TRMPDAAQTT VPLQLGVGGH LHGWPVLVFI LGVLLTFALI VRKAPGAILI SIVGMTVLAV
ILNAVTTIPS WGLTVPKWPG NPVASPDFGL VGHVSLFGGF SKVGVLTGVL FVFTVLLSCF
FDAMGTIMGV SDEAKLTDAE GYMPGINRVL FIDGLAVAAG GASSSSATTA FVESTAGVGE
GARTGLANVV TGGLFAVALF LTPVATMVPS QAATPALVAV GFLILSNSVK EIDWADYTIA
IPAFVTMLMM PFTYSITNGI GMGFITFVVL RLAAGRFREI PAAMYIVSAV FAFYYLMPAL
GLT
//
