ID A0A176L1F9_9ACTN Unreviewed; 2333 AA.
AC A0A176L1F9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:OAA98375.1};
GN ORFNames=A6P39_23120 {ECO:0000313|EMBL:OAA98375.1};
OS Streptomyces sp. FXJ1.172.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=710705 {ECO:0000313|EMBL:OAA98375.1};
RN [1] {ECO:0000313|EMBL:OAA98375.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAA98375.1};
RA Liu M., Liu N., Shang F., Huang Y.;
RT "Activation and identification of NC-1, a novel cryptic cyclodepsipeptide
RT from red soil-derived Streptomyces sp. FXJ1.172.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAA98375.1}.
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DR EMBL; LWRP01000113; OAA98375.1; -; Genomic_DNA.
DR STRING; 710705.A6P39_23120; -.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0018580; F:nitronate monooxygenase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR004136; NMO.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF03060; NMO; 2.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 721..1159
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1724..1810
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 285..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1690..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1812..1863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1720
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2333 AA; 240173 MW; ECB2ECE81AECEEB1 CRC64;
MTSPVRAHDL ILCLTPFGEP DARLAAAACA AGGLGILDLG SGDRRSREEL SRLGRAAPGP
FGIRVTGRCA LSPADVAGAP DTVVLTPDAT WKVTKLPPEY RVLMEVTDLG QARAAVRAGA
RGLIARGGES GGRVGELSTF VLLQQLLSDG ELSGVPVWAC GGIGPRTGAA AVAGGAAGVV
LDSQLGLLPE SGLPESVRAA LRSLDGSETV VLGGHRVLRR RGPESPQPPA DDPGTVASLL
GAGTPHAQLL PVGQDGFLAA RFAERWGDVR GVVREMSAAI QYVTHTGPMT TPGTPEPTAA
ADGGARTVPA VSRDAADAGP AVSRDVADAG PVVARGAGRP GPADALRAGS GMCRVLGTRL
PVAQGPMTRV SDQAGFAAAV AEGGALPFLA LALADGERTR AMLTEARGVL DGRPWGVGVL
GFAPEEIRNA QLDAVRELRP THAVIAGGRP AQAETLERAG IRTFLHVPSP GLLRQFLEAG
ARRFVFEGSE CGGHVGPRAS FPLWEAQLAV IEDYFAAAGD EAIRQLEVFF AGGIHDERSA
AMVAALAAQL TARGAAVGLL MGTAYLFTTE AVAHGAIRPL FQRQVLTATA TALLETAPGH
ATRCVPSPFT GDYRDREAAL RAGGLTDREV WEGLERLNVG RLRIASKGVE RDADGALAAV
GEERQLTDGM FMAGQVAVLR ATTTTVADLH RAVTDGAADF LTRRAARPAP PATDEPPAPA
PLDIAIVGMA CMFPEAPDLA AFWANVVTGR DAVTEVPPER WDPAVHHSAG RTASKWGGFL
PRIPFDPLRY GIPPASLGSI EPVQLLSLEA ARRALEDAGY GERGRAFDRA RTSVVFGAEA
GSDLSNAATL RAVLPAYYGR VPEGIEEQLP RLTEDSFPGM LANVISGRIA NRLDLGGANF
TVDAACASSL AALDVACKEL VSGTSDLVLC GGADLHNGIN DYVLFSAVHA LSPTGRSRAF
DSSADGIALG EGVACLVLKR LTDAERDGDR IYGVVKGLGS ASDGRSLGLT APRPEGQRAA
LERAYRNAAV SPADVGLVEA HGTGTVVGDR TELTVLSEVF TEAGASAGSC ALGSVKSQIG
HTKCAAGLAG LIKTTLALYT AVTPPTLHLE RPNPAWTQGD SPFAFHTRAR PWTAPAAQRF
AGVSAFGFGG TNFHAVLAAH TRAVPPAQSL DAWPCELLLF RGRDTAAAHR TVAEILRAAE
ADGRPWRLRD LALAAARRAD TAHEPVRAAV VARDIEELTV QLRRILAGDH DPAAGIHGAD
PVPGETAFLF PGQGSQRTGM LADLLVTLPE LRHFLHLGRA HAEAVHPPAA FDDTARERHR
AALTDTRAAQ PALGIAGLAA HAFLTSAGVH PDQAAGHSYG ELAALAAAGA LDPETLLELS
GARAGAILAA AGDDPGTMAA VGAPAAAVTD VLRTAEAPAS VVVANLNSPE QTVISGPTAD
VATAVRLLRA AGLGAKRIPV ACAFHSPLVA AAGERFAKIL ADKTVRAPEF PVWANRTAAP
YPADPDAVRA ELAAQIGAPV DFAAQIEAMY EAGARLFVEA GPGTVLTRLV GQILGDRPHR
TVACEPEAGS GLRGWLDALA RLAVAGQPVR TAWLLRGRDA VDALRAPAPE RPGWTVDGHL
VRTADGALLP GALAPARRVV ETTVTTDQPS GAPTDRDALI SEFLRTSREM IAAQRDVLLT
YFGATPGAAP APAPVPPPVS PAVQPAAREL PPPEPQLPLL PATGPADDVD RVVLEIISER
TGYPVDMIEP DLDLEADLSI DSIKRAEIAG ELAKRLGIAA GAEVLADAEL EELAKARTAA
AVTQWLTARA GAGTGAGGGG EPAGERAQTS YPGARTQEPA SVQGVPPRRC ELRPVPLPEP
GPADAGLSGR RFALLGGEGV AAAVAARLTG HGADAVLLDR GHLLTEADGP VDAVVYLGAL
PGPGLPALPD AFPVLRAALA CGPRALLAVR AAERAPALRA AGLDGLLRTV GREYPGLLAR
IVAVPDTAPA AVAEAVLAEL CAPQPAAPVV LRTAAGTRQG LELVPVPLGP LGTTGAGPAA
DGAAEAAALG LDRDSVVLLA GGARGITARF AATLARACRC RLELLGRTAA PTAPEDPRTA
AARTPAELRA ALAAGPDAPT PAEINRAAEL TLAQREITTT LAELGALGSE ARYRAVDFRE
RDAVLQAVKE IHAEHGRLDG VVFAAGVIED RLIADKTPES FQRVYGTKTA GAAALFAALD
DLPAAPAFTV LFGSIAAVLG NRGQADYAAA NDALEALGAD WAARTGHRAL TVHWGPWAPS
GTHTGMVGEE LGREYARRGV GLIDPDEGTA ALLRELAWGD PAARAVVHTA SGW
//
