ID A0A176L1J2_9ACTN Unreviewed; 401 AA.
AC A0A176L1J2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:OAA98402.1};
GN ORFNames=A6P39_23280 {ECO:0000313|EMBL:OAA98402.1};
OS Streptomyces sp. FXJ1.172.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=710705 {ECO:0000313|EMBL:OAA98402.1};
RN [1] {ECO:0000313|EMBL:OAA98402.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAA98402.1};
RA Liu M., Liu N., Shang F., Huang Y.;
RT "Activation and identification of NC-1, a novel cryptic cyclodepsipeptide
RT from red soil-derived Streptomyces sp. FXJ1.172.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAA98402.1}.
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DR EMBL; LWRP01000113; OAA98402.1; -; Genomic_DNA.
DR RefSeq; WP_067049540.1; NZ_CP119133.1.
DR AlphaFoldDB; A0A176L1J2; -.
DR STRING; 710705.A6P39_23280; -.
DR OrthoDB; 9780685at2; -.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:UniProt.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2}.
FT MOD_RES 221
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 401 AA; 41891 MW; 0C98F90507929ED7 CRC64;
MDTASIGAYD GVRTASRALA TEAVHAGRDD LARQGLHAPP IDLSTTYPSY DSRAEAARID
AFATDGADPA GPPVYGRLGN PTVARFETAL ARLEGTGAAV AFASGMAALS AVLLARSAMG
LRHVVAVRPL YGCSDHLLTA GLLGTEVTWT DPAGITDALR PDTGLVLVES PANPTLAELD
LRAVAHACGS VPLLADNTFA TPVLQRPAEQ GARLVLHSAT KYLGGHGDVL AGVVACDEEF
AGRLRQIRFA TGGVLHPLAG YLLLRGLSTL PVRVRAASAN AAELARRLTA DPRVARVHYP
RLGGAMIAFE VYGDPHEVIS RVRLVTPAVS LGSVDTLIQH PASISHRIVD ADDRRGAGVS
DRLLRLSVGL EDIDDLWADL DQALGAPQDQ QALGYARSGT A
//
