ID A0A176U5N2_9FIRM Unreviewed; 459 AA.
AC A0A176U5N2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-SEP-2017, entry version 11.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN ORFNames=HMPREF2738_01924 {ECO:0000313|EMBL:OAD88063.1};
OS Clostridiales bacterium KLE1615.
OC Bacteria; Firmicutes; Clostridia; Clostridiales.
OX NCBI_TaxID=1715004 {ECO:0000313|EMBL:OAD88063.1, ECO:0000313|Proteomes:UP000077212};
RN [1] {ECO:0000313|EMBL:OAD88063.1, ECO:0000313|Proteomes:UP000077212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KLE1615 {ECO:0000313|EMBL:OAD88063.1,
RC ECO:0000313|Proteomes:UP000077212};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the initiation and regulation
CC of chromosomal replication. Binds to the origin of replication; it
CC binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC ECO:0000256|SAAS:SAAS00756131}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC ECO:0000256|SAAS:SAAS00555179}.
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data. {ECO:0000313|EMBL:OAD88063.1}.
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DR EMBL; LXPQ01000148; OAD88063.1; -; Genomic_DNA.
DR RefSeq; WP_066561137.1; NZ_KV441351.1.
DR EnsemblBacteria; OAD88063; OAD88063; HMPREF2738_01924.
DR PATRIC; fig|1715004.3.peg.1915; -.
DR Proteomes; UP000077212; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW Complete proteome {ECO:0000313|Proteomes:UP000077212};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|SAAS:SAAS00756112};
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW Reference proteome {ECO:0000313|Proteomes:UP000077212}.
FT DOMAIN 152 280 AAA. {ECO:0000259|SMART:SM00382}.
FT DOMAIN 364 433 Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT NP_BIND 160 167 ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ SEQUENCE 459 AA; 52496 MW; F003BD3766261894 CRC64;
MIDRLKENWD AIKDTLKENY DISKVSYDTW IVPMEIHNVD NDQVYILADT KGIPNILDYI
KKKYKQILEI VIEEKIGLHC NVIFVTSEDL EKRPNLTAEA SNIVTPELNS YYAAVMNANL
NPRYTFDTFV VGSNNRFAHA ASLAVAESPG TLYNPLFIYG GAGLGKTHLM QSIAHYILRN
DPSVRVLYVT SETFTNDLID SLKGKKNAEF KEKYRSIDVL MIDDIQFLIG KESTQEEFFH
TFNYLYETGK QVIITSDKPP KDFTNLEERL RSRFSVGLPV DVSAPDYETR VAILHKKEET
ENTKISDDII NYIAENINTN IRELEGALNR ITAFKRLSNK EITLSMAEDV LRDIINNHKE
VTITVPLIVE VIASHFGFEA DELLSQKRNK DIAYSRQIAM YLCRQMTDLS LQQIGKELGN
RDHTTVRHGI EKITEDLKNS QFLQDTIDVL QKKINPALG
//
