ID A0A176U6W0_9FIRM Unreviewed; 567 AA.
AC A0A176U6W0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Papain family cysteine protease {ECO:0000313|EMBL:OAD88386.1};
GN ORFNames=HMPREF2738_01612 {ECO:0000313|EMBL:OAD88386.1};
OS Clostridiales bacterium KLE1615.
OC Bacteria; Bacillota; Clostridia; Eubacteriales.
OX NCBI_TaxID=1715004 {ECO:0000313|EMBL:OAD88386.1, ECO:0000313|Proteomes:UP000077212};
RN [1] {ECO:0000313|EMBL:OAD88386.1, ECO:0000313|Proteomes:UP000077212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KLE1615 {ECO:0000313|EMBL:OAD88386.1,
RC ECO:0000313|Proteomes:UP000077212};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAD88386.1}.
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DR EMBL; LXPQ01000118; OAD88386.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A176U6W0; -.
DR PATRIC; fig|1715004.3.peg.1609; -.
DR Proteomes; UP000077212; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02619; Peptidase_C1; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR012854; Cu_amine_oxidase-like_N.
DR InterPro; IPR040528; Lectin-like.
DR InterPro; IPR036582; Mao_N_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF07833; Cu_amine_oxidN1; 1.
DR Pfam; PF18560; Lectin_like; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF55383; Copper amine oxidase, domain N; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:OAD88386.1};
KW Protease {ECO:0000313|EMBL:OAD88386.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077212}.
FT DOMAIN 178..400
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 567 AA; 62984 MW; D821B0A43466C7D0 CRC64;
MKYKQWYIAA ALALLVLAVV CLYQRQTTST VRSGYTQAGV CDEWNELIAA KTNQKEISLS
VDGKRLAKND IQPYMADDRQ LMIPVDTLRD VFLCNVGIYD HKTLKAYRND RSIEAEENAE
EIVINGEKEN ITNALVFQGG SYYLSADVVA KGLDYEVEWD ASANTIRFTD IRPEASKLPS
AFDPRLYGLD APVMNQGKLG TCWAFASVGA LEAALLPEES WNFSVDHMSL NNGYTWGQDT
GGEYTMAMAY LLSWKGPVRE EDDPYGDGKT DTSLRAVKHV QEIQIIPSKD QSAIKRAVYL
YGSVQTSIYC EVSGENSESS YYNNAQNAYC YIGTNKINHD TLIVGWDDGY AASNFRTQPE
GNGAWLCMNS WGTGFGDGGY FWVSYYDSNV GIYNAAYTKI ENTDNYDRIY QSDKCGWVGQ
LGYGNEEAYF ANLYTANGDE VLEAVGFYAT APDTSYEVYV VNKVTGEADL TFQKKAASGS
FSNAGYYTVK LDKPVLLSDG DRYAVIVYVR TPGSERPVAV EYTSKDGAVI ANLSGNEGYI
SMKGTSWQSA QDKYNCNICL KAYTKEQ
//
