ID A0A177CU10_9PLEO Unreviewed; 988 AA.
AC A0A177CU10;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DUF221-domain-containing protein {ECO:0000313|EMBL:OAG10498.1};
GN ORFNames=CC84DRAFT_486326 {ECO:0000313|EMBL:OAG10498.1};
OS Paraphaeosphaeria sporulosa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Massarineae; Didymosphaeriaceae;
OC Paraphaeosphaeria.
OX NCBI_TaxID=1460663 {ECO:0000313|EMBL:OAG10498.1, ECO:0000313|Proteomes:UP000077069};
RN [1] {ECO:0000313|EMBL:OAG10498.1, ECO:0000313|Proteomes:UP000077069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP3s5-JAC2a {ECO:0000313|EMBL:OAG10498.1,
RC ECO:0000313|Proteomes:UP000077069};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KV441549; OAG10498.1; -; Genomic_DNA.
DR RefSeq; XP_018040863.1; XM_018186469.1.
DR AlphaFoldDB; A0A177CU10; -.
DR GeneID; 28769955; -.
DR InParanoid; A0A177CU10; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000077069; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000077069};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 36..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..187
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 211..377
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 389..669
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 851..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 988 AA; 112224 MW; 31690E505B57C248 CRC64;
MNVYPRQSSG SGSDSTDQFL NLIADPFQAE VQQNSIYAAI VYAFAISGAL FLLFCILRPR
NSRVYAPRAK HADEKHAPRQ LDRKPLGWIA AIRGVKEQEL VEKIGLDAVV FLRFLRMLRN
IFLVLSVFGC GILIPINVVG GSAFYEQWDN VATLMKFTPQ YIFGPKFWAF VICSYLFQGT
ICGFLWWNYR AVYRLKRAYF ESADYQQSLH SRTLLLTHIP ESSRTDDGIA ELVNIAKPTQ
TLPRTAIGRN VKDLPKLIEA HGEAVRELEA VLAKYLNNPE RLPEKRPMCE PEKDDRSIYG
KHKVDAIDYL TDRISRLEIQ IKEVRETVDK RNPTPYGFAS YPRIEDAHAV AYASKKKGPK
GCDVYLAPKP HDLLWQNLPM TRRTRRARMF WDGLWMILFT AAYIVPNIAT SVFLSDFSHL
GLVWPAFQTN LVAHPTGWGI AQGILAPTVQ TLIYMGIPVM FRRLYTHSGD VSKTSRERHV
TARLYIFFVF NNLIVFSIFG SAWRFVATVI AAKDQGIWEA IKSAHVFSKV MTGLCNMSTF
WLTWQMQKNL SAATDLAQAW PLVRSYIQRK LFTPTPRQLI ELSAPQPFMY AEYYNSYLQV
AVVGLTFGTL QPIILPVTAF YLAIECWFKK YMVQYVLITK TESGGRFWRL LVNRMLISVA
LGNAVIALVV GAQGVGSINS VRNGNMLYAM IPLPLLLLAF KWYCKRAFDD KLIYYSTQPF
SDAEDAASPD GKKMKRNDRV AVRFGHPALY KKLITPMVHA KSQHLLKEIY GHRSSIGDRN
IFEAPHRRST DRAMPTTPYG YSDVFMAEMD SAEPGKPVPV AQDLPSVELV AEEDLDFENF
KKRAEFREQF GGDGELYGRP EDLISRPGTP STFATLNGSG FFPQKVTGES STRASSATKR
GSDDEPSRDH EEGVLYGPGY QRTPLRDHFE EVDVDIPATP FDADEVLQAG RVVRQDSHGR
LLQEEGNREV EYFPGFYKED TSYDRSRR
//
