ID A0A177D096_9PLEO Unreviewed; 306 AA.
AC A0A177D096;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Putative sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating {ECO:0000313|EMBL:OAG12861.1};
GN ORFNames=CC84DRAFT_1183394 {ECO:0000313|EMBL:OAG12861.1};
OS Paraphaeosphaeria sporulosa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Massarineae; Didymosphaeriaceae;
OC Paraphaeosphaeria.
OX NCBI_TaxID=1460663 {ECO:0000313|EMBL:OAG12861.1, ECO:0000313|Proteomes:UP000077069};
RN [1] {ECO:0000313|EMBL:OAG12861.1, ECO:0000313|Proteomes:UP000077069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP3s5-JAC2a {ECO:0000313|EMBL:OAG12861.1,
RC ECO:0000313|Proteomes:UP000077069};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; KV441548; OAG12861.1; -; Genomic_DNA.
DR RefSeq; XP_018043226.1; XM_018180685.1.
DR AlphaFoldDB; A0A177D096; -.
DR STRING; 1460663.A0A177D096; -.
DR GeneID; 28764171; -.
DR InParanoid; A0A177D096; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000077069; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000077069}.
FT DOMAIN 86..219
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 306 AA; 34278 MW; DDF9E5C3094019E5 CRC64;
MDPPSPQQTV QGLGNVLVIG GCGLLGHHIV KFLVENGKPS DGNFVFDLSS VFARCNIVGV
QIIANCAQEQ GIPVLVHLSS SEEDLVNGSV YAKTKAIEEG LVIPANRQRS LLTTAIRLCT
LVREEDRVLT RQFIELGRKG TIKSQVRHGK NMDDFIYAGN AAEGHLIAAQ ALLHTASSDA
SIPANKHVDG EAFNMTNDEP WPFWEAARFV SNTTGFPMAE HEVWKIPMEL VYFFMAIWEA
IYWVFMLGGE PEVKARVLRY TQQVRTFDIT KAREGLGFEP RVTLEERFRR GVNWHREQDK
QKAKSL
//
